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Tumor Biology

, Volume 31, Issue 2, pp 97–102 | Cite as

Serum micronutrient and antioxidant levels at baseline and the natural history of men with localised prostate cancer on active surveillance

  • Ramachandran Venkitaraman
  • Karen Thomas
  • Phillip Grace
  • David P. Dearnaley
  • Alan Horwich
  • Robert A. Huddart
  • Christopher C. Parker
Research Article

Abstract

The aim of this study was to determine whether serum concentrations of micronutrients, antioxidants and vitamins predict rate of disease progression in untreated, localised prostate cancer. Patients with localised prostatic adenocarcinoma on a prospective study of active surveillance underwent monitoring with serial PSA levels and repeat prostate biopsies. Disease progression was defined as either adverse histology on repeat biopsy (primary Gleason grade ≥4 or >50% positive cores of total) or radical treatment for PSA velocity >1 ng ml−1 year−1. Time to disease progression was analysed with respect to baseline levels of alpha-tocopherol, gamma-tocopherol, alpha-carotene and beta-carotene, lycopene, retinol and selenium. One hundred four patients were evaluable, with a median follow-up of 2.5 years. Thirty-eight patients experienced disease progression, 13 biochemical and 25 histologic progression. Median time to disease progression was 2.62 years. No significant association was seen between time to disease progression and baseline serum levels of alpha-tocopherol (p = 0.86), gamma-tocopherol (p = 0.84), alpha-carotenoid (p = 0.66), beta-carotene (p = 0.65), lycopene (p = 0.0.15), retinol (p = 0.76) or selenium (p = 0.76). No significant association was seen between serum levels of the micronutrients, antioxidants or vitamins and either adverse histology on repeat biopsy or PSA velocity. Our data do not support the hypothesis that high serum concentrations of micronutrients, antioxidants and vitamins prevent disease progression in men with localised prostate cancer.

Keywords

Prostate Active surveillance Antioxidants Micronutrients Vitamins 

Notes

Acknowledgements

This work was undertaken in The Royal Marsden NHS Trust which received a proportion of its funding from the NHS Executive; the views expressed in this publication are those of the authors and not necessarily those of the NHS Executive. This work was supported by the Institute of Cancer Research, the Cancer Research UK Section of Radiotherapy (CRUK) grant no. C46/A2131 and the NCRI South of England Prostate Cancer Collaborative.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2010

Authors and Affiliations

  • Ramachandran Venkitaraman
    • 1
  • Karen Thomas
    • 2
  • Phillip Grace
    • 3
  • David P. Dearnaley
    • 4
  • Alan Horwich
    • 4
  • Robert A. Huddart
    • 4
  • Christopher C. Parker
    • 4
  1. 1.Department of Clinical OncologyIpswich Hospital NHS TrustIpswichUK
  2. 2.Computing Department, Urology UnitRoyal Marsden NHS Foundation TrustSuttonUK
  3. 3.HFL Limited, FordhamCambridgeUK
  4. 4.Academic Unit of Radiotherapy & OncologyInstitute of Cancer ResearchSurreyUK

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