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Plantamajoside ameliorates TGFβ2-induced autophagy, epithelial–mesenchymal transition and inflammatory processes in human lens epithelial cells

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Abstract

Background

Posterior capsular opacification (PCO) is the most common postoperative complication after cataract surgery, occurring in > 25% of adults. To combat this disease, new and more targets and drugs are still urgently needed. Plantamajoside (PMS) is a natural compound extracted from planajoside and has a wide range of biological activities. However, the role and effects of PMS in PCO are still unclear.

Objectives

To uncover the possible effects of plantamajoside (PMS) on posterior capsular opacification (PCO) progression and clarify the mechanism.

Results

PMS inhibited the proliferation of hLECs. PMS inhibited the autophagy of hLECs. Furthermore, PMS suppressed the motility and EMT of hLECs induced by TGFβ2. PMS suppressed the TGFβ2-induced inflammation of hLECs. Mechanically, PMS restrained the AGEs–RAGE axis, therefore, inhibiting PCO progression.

Conclusion

PMS could serve as a promising drug for PCO treatment.

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Data availability

All data generated or analyzed during this study are included in this published article. The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.

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Acknowledgements

Not applicable.

Funding

This work was supported by the Scientific Research Project Weifang City Health Committee. (Grant No. WFWSJK-2021-002).

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Authors and Affiliations

  1. Department of Ophthalmology, Weifang Eye Hospital, Zhengda Guangming Eye Group, No. 139 Xingfu Street, Kuiwen District, Weifang City, 261000, Shandong Province, China

    Xiaoxiang Sun & Xinyan Xu

  2. Department of Ophthalmology, Qingdao Zhengda Guangming Eye Hospital, Zhengda Guangming International Eye Research Center, Qingdao University, Qingdao, 266000, Shandong, China

    Xuequan Sun

  3. Department of Ophthalmology, Weifang Eye Hospital Co., Ltd., Weifang, 261000, Shandong, China

    Yuxuan Wang

  4. Department of Ophthalmology, Rizhao Zhengda Guangming Eye Hospital, Rizhao, 276500, Shandong, China

    Susu Lu

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  1. Xiaoxiang Sun
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Contributions

Xiaoxiang Sun designed the study, completed the experiment and supervised the data collection, Xuequan Sun analyzed the data, interpreted the data, Xinyan Xu, Yuxuan Wang and Susu Lu prepare the manuscript for publication and reviewed the draft of the manuscript. All authors have read and approved the manuscript.

Corresponding author

Correspondence to Xinyan Xu.

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Author Xiaoxiang Sun declares that he/she has no conflict of interest; author Xuequan Sun declares that he/she has no conflict of interest; author Xinyan Xu declares that he/she has no conflict of interest; author Yuxuan Wang declares that he/she has no conflict of interest; author Susu Lu declares that he/she has no conflict of interest.

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Sun, X., Sun, X., Xu, X. et al. Plantamajoside ameliorates TGFβ2-induced autophagy, epithelial–mesenchymal transition and inflammatory processes in human lens epithelial cells. Mol. Cell. Toxicol. (2024). https://doi.org/10.1007/s13273-024-00456-4

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