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The effect of cyfluthrin on testis inhibin B in rats and the intervention of Lycium barbarum polysaccharide

Abstract

Background

In recent years, studies have shown that cyfluthrin is harmful to the reproductive system. Lycium barbarum polysaccharide may be a protective agent.

Objective

To investigate the effect of cyfluthrin (Cy) on testosterone B (inhibin B, INHB) in male rats and the intervention of Lycium barbarum polysaccharide (LBP).

Results

Compared with the control group, the mRNA and protein expression levels of INH α and INH βB in the testis tissue decreased, and the difference was statistically significant (P < 0.05). The LBP intervention group can significantly increase the expression level, and the difference is statistically significant (P < 0.05).

Conclusion

The decrease of INHα and INHβB expression caused by Cy exposure indicates that Cy has a toxic effect on the testis of rats, and the addition of LBP has a certain protective effect on the testis of rats.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (81960584).

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Authors and Affiliations

Authors

Contributions

ZG designed and executed the research and wrote the manuscript. YX contributed to animal experiments, and CG and JW participated in the statistical analysis of the data. HY revised the manuscript and coordinated research. All authors have read and approved the final version of the manuscript.

Corresponding author

Correspondence to Hui-Fang Yang.

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The authors declare that they have no competing interests.

Human and animal rights

The animal use protocol listed below has been reviewed and approved by the Laboratory Animal Ethical and Welfare Committee of laboratory Animal Center, Ningxia Medical University.(Approval No. IACUC-NYLAC-2019–076).

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Guo, X., Xie, YX., Guo, C. et al. The effect of cyfluthrin on testis inhibin B in rats and the intervention of Lycium barbarum polysaccharide. Mol. Cell. Toxicol. 17, 151–160 (2021). https://doi.org/10.1007/s13273-021-00120-1

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  • DOI: https://doi.org/10.1007/s13273-021-00120-1

Keywords

  • Cyfluthrin
  • Rats
  • Testis Inhibin B
  • Lycium barbarum polysaccharide