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Perfluorooctane sulfonate exacerbates mast cell-mediated allergic inflammation by the release of histamine

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Abstract

Backgrounds

Mast cells play a major role in allergic inflammation by the release of histamine, an important mediator of type I hypersensitivity. Cencerns regarding potential harmful effects of perfluorooctane sulfonate (PFOS) have been raised. Previous studies reported that PFOS causes various adverse effects such as immunotoxicity and neurotoxicity. This report studied whether PFOS affects mast cells-mediated allergic inflammation.

Methods

Ovalbumin-induced active systemic anaphylaxis model was used to assess for the type I hypersensitivity. After sensitization, mice were orally administered with PFOS and then allergic symptoms such as hypothermia and increase of serum allergic mediator were measured. In additional, this study investigated whether PFOS deteriorate allergic inflammation in immunoglobulin E-stimulated mast cells.

Results

PFOS aggravated the allergic symptoms such as hypothermia, and increase of serum histamine, tumor necrosis factor-α and immunoglobulin (Ig) E/ G1. PFOS increased the release of histamine and β-hexosaminidase through the up-regulation of intracellular calcium in IgE-stimulated mast cells. PFOS also enhanced the gene expression of pro-inflammatory cytokines by activating nuclear factor-κB.

Conclusion

This study demonstrated that PFOS more intensifies the mast cell-mediated allergic inflammation.

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Authors and Affiliations

  1. Cell and Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

    Jun-Kyoung Lee, Soyoung Lee, Young-Ae Choi, Meiling Jin, Yeon-Yong Kim, Byeong-Cheol Kang, Min-Jong Kim, Hima Dhakal & Sang-Hyun Kim

  2. Immunoregulatory Materials Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea

    Soyoung Lee

  3. National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Republic of Korea

    Sang-Rae Lee & Sun-Uk Kim

  4. Department of Physiology, School of Medicine, Gachon University, Incheon, Republic of Korea

    Dongwoo Khang

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  1. Jun-Kyoung Lee
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Correspondence to Dongwoo Khang or Sang-Hyun Kim.

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Lee, JK., Lee, S., Choi, YA. et al. Perfluorooctane sulfonate exacerbates mast cell-mediated allergic inflammation by the release of histamine. Mol. Cell. Toxicol. 14, 173–181 (2018). https://doi.org/10.1007/s13273-018-0019-z

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