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Corni fructus ameliorates menopause symptom in 4-vinylcyclohexene diepoxide

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Abstract

Menopause is considered to mean falling levels of ovarian estradiol and progesterone. Menopause syndrome can lead to hot flashes, headaches, and depression etc. Corni Fructus (CF) was used as a therapeutic herbal medicine for treating various diseases such as pain, diabetic nephropathy and tuberculosis. This study was conducted to evaluate the protective effects of CF in follicle depletion of a mice model using the industrial chemical 4-vinylcyclohexene diepoxide (VCD). VCD directly targets prenatal follicles. Mice were injected with VCD (160 mg/kg) daily for 15 days and administered CF 18 times after VCD injection. CF treatment reduced body weight, tail skin temperature, and uterus weight. In addition, CF treatment significantly decreased total cholesterol, low-density lipoprotein, low-density lipoprotein/high-density lipoprotein ratio, and osteocalcin levels as well as correcting skin temperature. These results support the therapeutic potential of CF for those who suffer from menopause symptoms.

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Physiology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul, 02447, Republic of Korea

    Dasom Shin, Geun-Hyung Kang, Sejun Kim & Hyunsu Bae

  2. Department of Anatomy-Pointology, College of Korean Medicine, Gachon University, Seongnam, 13120, Republic of Korea

    Myeong Shin Koh, Sangchul Lee & Youn-Sub Kim

  3. Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul, 02447, Republic of Korea

    Da Hye Lee & Dae Sik Jang

  4. Department of Obsterics and Gynecology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul, 02447, Republic of Korea

    Deok-Sang Hwang

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  1. Dasom Shin
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  2. Myeong Shin Koh
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Correspondence to Youn-Sub Kim or Hyunsu Bae.

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Shin, D., Koh, M.S., Lee, S. et al. Corni fructus ameliorates menopause symptom in 4-vinylcyclohexene diepoxide. Mol. Cell. Toxicol. 14, 35–42 (2018). https://doi.org/10.1007/s13273-018-0005-5

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