Molecular & Cellular Toxicology

, Volume 13, Issue 2, pp 207–212 | Cite as

Altered miRNA expression in lung tissues of patients with chronic obstructive pulmonary disease

  • Woo Jin Kim
  • Jae Hyun Lim
  • Yoonki Hong
  • Seok-Ho Hong
  • Chi Young Bang
  • Jae Seung Lee
  • Yeon-Mok Oh
  • Ju Han KimEmail author
Original Paper


Chronic obstructive pulmonary disease (COPD) is a complex disorder characterized by airflow limitation. Epigenetic control affects gene expression in the lung, and microRNAs (miRNAs) are one of the primary types of epigenetic modifiers. In this study, lung tissues were obtained from 15 COPD patients and 11 subjects with normal lung function. RNA was isolated from the samples, and small RNA sequencing was performed and miRNAs that were differentially expressed between the COPD and control lungs were identified. A total of 12 miRNAs were shown to be differentially expressed (false discovery rate (FDR)<0.05) between the lung tissues of COPD and control subjects. Based on the predicted target mRNAs of differentially expressed miRNAs, the gene ontologies that were most enriched were nuclear lumen and transcription initiation. Further investigation of these miRNAs and their target genes will enhance our understanding of the molecular mechanisms involved in COPD.


Chronic obstructive pulmonary disease microRNA Sequencing 


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Copyright information

© The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Woo Jin Kim
    • 1
  • Jae Hyun Lim
    • 2
  • Yoonki Hong
    • 1
  • Seok-Ho Hong
    • 1
  • Chi Young Bang
    • 1
  • Jae Seung Lee
    • 3
  • Yeon-Mok Oh
    • 3
  • Ju Han Kim
    • 2
    Email author
  1. 1.Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, School of MedicineKangwon National UniversityChuncheonRepublic of Korea
  2. 2.Seoul National University Biomedical Informatics and Systems Biomedical Informatics Research Center, Division of Biomedical InformaticsSeoul National University College of MedicineSeoulRepublic of Korea
  3. 3.Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea

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