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Complete genome sequence of Deinococcus swuensis, a bacterium resistant to radiation toxicity

Molecular & Cellular Toxicology volume 11, pages 315–321 (2015)Cite this article

Abstract

Deinococcus swuensis DY59T is a Grampositive, coccus-shaped bacterium. Most members of the genus Deinococcus are able to grow in the presence of high levels of chronic radiation toxicity and desiccation because they can protect enzymes from reactive oxygen species generated during ionizing radiation. The mechanisms behind the resistance to radiation toxicity and the genomic features of resistance could be useful to exploit Deinococcus swuensis in the biotechnological applications such as detoxification of xenobiotic contaminated with radioactive wastes. Strain DY59T showed resistance to gamma radiation with a D10 value (i.e. the dose required to reduce the bacterial population by 10-fold) in excess of 5 kGy. However, the genus Deinococcus is slightly characterized at the genome level, despite its potential importance. Thus, the present study determined the features of Deinococcus swuensis DY59T, as well as its genome sequence and annotation. The genome comprised of 3,531,443 bp with a G + C content of 67.4%, which included 3,305 protein-coding genes and 58 RNA genes. Based on the genome annotation, the strain DY59T undergoes prokaryotic type nucleotide excision repair pathway, restores the damaged gene, and resists the ionizing radiation toxicity.

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Authors and Affiliations

  1. Department of Bio & Environmental Technology, College of Natural Science, Seoul Women’s University, Seoul, 139-774, Korea

    Myung Kyum Kim, Sathiyaraj Srinivasan & Eun Sun Joo

  2. National Institute of Horticultural & Herbal Science, RDA, 100 Nongsaenyeong-ro, Iseo-myeon, Wanji-gun, Jeollabuk-do, Korea

    Chang-Gi Back

  3. College of Agricultural and Life Sciences, Kyungpook National University, Daegu, 702-701, Korea

    Chang-Gi Back, Seung-Yeol Lee & Hee-Young Jung

  4. Institute of Plant Medicine, Kyungpook National University, Daegu, 702-701, Korea

    Hee-Young Jung

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  1. Myung Kyum Kim
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  2. Sathiyaraj Srinivasan
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  4. Eun Sun Joo
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  5. Seung-Yeol Lee
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Correspondence to Hee-Young Jung.

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Kim, M.K., Srinivasan, S., Back, CG. et al. Complete genome sequence of Deinococcus swuensis, a bacterium resistant to radiation toxicity. Mol. Cell. Toxicol. 11, 315–321 (2015). https://doi.org/10.1007/s13273-015-0031-5

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  • DOI: https://doi.org/10.1007/s13273-015-0031-5

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