Molecular & Cellular Toxicology

, Volume 9, Issue 1, pp 51–56 | Cite as

Evaluation of comparative cytotoxicity of spray-type chemicals used in household products

  • Jung-Taek Kwon
  • Gyun-Baek Seo
  • Hyun-Mi Kim
  • Ilseob Shim
  • Byoungcheun Lee
  • Ji-Youn Jung
  • Pilje Kim
  • Kyunghee Choi
Original Paper

Abstract

Chemicals are widely used in our daily lives for various purposes such as disinfectant, air fresher, paints and hair spray. However, their pulmonary toxicity has less studied compared with oral and dermal toxicity. Therefore, the purpose of this study was to examine comparative cytotoxicity of triclosan (TCS), benzisothiazolinone (BIT), dichlorophene (DCP) and citral (CTR) major using spray-type chemicals used in household products (CHPs) in Korea. TCS, DCP and BIT induced more severe mitochondria injury and cell membrane damage than CTR in lung epithelial cell during 24 hrs exposure. Furthermore, the result of clonogenic assay revealed that exposure of CHPs significantly decreased colony size and that BIT reduced cell growth at most compared with TCS, DCP and CTR. In summary, results of comparative cytotoxicity demonstrated that inhalation of TCS, DCP and BIT may cause pulmonary toxicity. Therefore, our results suggest that TCS, BIT and DCP are requiring inhalation toxicity assessment for maintaining a high quality of life.

Keywords

Cytotoxicity Triclosan Benzisothiazolinone Dichlorophene Citral 

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Copyright information

© The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Jung-Taek Kwon
    • 1
  • Gyun-Baek Seo
    • 1
    • 2
  • Hyun-Mi Kim
    • 1
  • Ilseob Shim
    • 1
  • Byoungcheun Lee
    • 1
  • Ji-Youn Jung
    • 2
  • Pilje Kim
    • 1
  • Kyunghee Choi
    • 1
  1. 1.Environmental Health Research DepartmentNational Institute of Environmental ResearchIncheonKorea
  2. 2.Department of Companion and Laboratory Animal ScienceKongju National UniversityYesanKorea

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