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Evaluation of comparative cytotoxicity of spray-type chemicals used in household products

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Abstract

Chemicals are widely used in our daily lives for various purposes such as disinfectant, air fresher, paints and hair spray. However, their pulmonary toxicity has less studied compared with oral and dermal toxicity. Therefore, the purpose of this study was to examine comparative cytotoxicity of triclosan (TCS), benzisothiazolinone (BIT), dichlorophene (DCP) and citral (CTR) major using spray-type chemicals used in household products (CHPs) in Korea. TCS, DCP and BIT induced more severe mitochondria injury and cell membrane damage than CTR in lung epithelial cell during 24 hrs exposure. Furthermore, the result of clonogenic assay revealed that exposure of CHPs significantly decreased colony size and that BIT reduced cell growth at most compared with TCS, DCP and CTR. In summary, results of comparative cytotoxicity demonstrated that inhalation of TCS, DCP and BIT may cause pulmonary toxicity. Therefore, our results suggest that TCS, BIT and DCP are requiring inhalation toxicity assessment for maintaining a high quality of life.

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Authors and Affiliations

  1. Environmental Health Research Department, National Institute of Environmental Research, Incheon, 404-708, Korea

    Jung-Taek Kwon, Gyun-Baek Seo, Hyun-Mi Kim, Ilseob Shim, Byoungcheun Lee, Pilje Kim & Kyunghee Choi

  2. Department of Companion and Laboratory Animal Science, Kongju National University, Yesan, 340-702, Korea

    Gyun-Baek Seo & Ji-Youn Jung

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  1. Jung-Taek Kwon
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  2. Gyun-Baek Seo
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  3. Hyun-Mi Kim
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  4. Ilseob Shim
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  5. Byoungcheun Lee
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  6. Ji-Youn Jung
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  7. Pilje Kim
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  8. Kyunghee Choi
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Correspondence to Jung-Taek Kwon or Hyun-Mi Kim.

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These authors contributed equally to this work

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Kwon, JT., Seo, GB., Kim, HM. et al. Evaluation of comparative cytotoxicity of spray-type chemicals used in household products. Mol. Cell. Toxicol. 9, 51–56 (2013). https://doi.org/10.1007/s13273-013-0008-1

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  • DOI: https://doi.org/10.1007/s13273-013-0008-1

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