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Protective role of thioredoxin reductase 1 in cadmium-induced DNA damage

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References

  1. Holmgren, A. & Lu, J. Thioredoxin and thioredoxin reductase: current research with special reference. Biochem Biophys Res Commun 396:120–124 (2010).

    Article  PubMed  CAS  Google Scholar 

  2. Becker, K., Gromer, S., Schirmer, R. H. & Müller, S. Thioredoxin reductase as a pathophysiological factor and drug target. Eur J Biochem 267:6118–6125 (2000).

    Article  PubMed  CAS  Google Scholar 

  3. Powis, G., Kirkpatrick, D. L., Angulo, M. & Baker, A. Thioredoxin redox control of cell growth and death and the effects of inhibitors. Chem Biol Interact 112: 23–34 (1998).

    Article  Google Scholar 

  4. Poole, L. B. et al. AhpF and other NADH: peroxiredoxin oxidoreductases, homologues of low Mr thioredoxin reductase. Eur J Biochem 26:6126–6133 (2000).

    Article  Google Scholar 

  5. Hirota, K. et al. Nucleoredoxin, glutaredoxin, and thioredoxin differentially regulate NF-kB, AP-1, and CREB activation in HEK293 cells. Biochem Biophys Res Commun 274:177–182 (2000).

    Article  PubMed  CAS  Google Scholar 

  6. Wei, S. J. et al. Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation. Cancer Res 60:6688–6695 (2000).

    PubMed  CAS  Google Scholar 

  7. IARC, Monographs on the Evaluation of Carcinogenic Risks to formation in DNA preferentially over strand breakage. Nucleic Acids Res. Humans, Vol. 58: Beryllium, Cadmium, Mercury, and Exposures in the Glass 18, 631–635. Manufacturing Industry. IARC, Lyon, France (1993).

    Google Scholar 

  8. Fay, R. M. & Mumtaz, M. M. Development of a priority list of chemical mixtures occurring at 1188 hazardous waste sites, using the HazDat database. Food Chem Toxicol 34:1163–1165 (1996).

    Article  PubMed  CAS  Google Scholar 

  9. Waalkes, M. P. Cadmium carcinogenesis. Mutat Res 533:107–120 (2003).

    Article  PubMed  CAS  Google Scholar 

  10. Friberg, L., Elinder, C., Kjellstrom, T. & Nordberg, G. F. Cadmium and health: A toxicological and epidemiological appraisal. CRC Press, Boca Raton, FL (1985).

    Google Scholar 

  11. Jin, T. et al. Renal dysfunction of cadmium-exposed workers residing in a cadmium-polluted environment. Biometals 17:513–518 (2004).

    Article  PubMed  CAS  Google Scholar 

  12. Prozialeck, W. C. et al. Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity. Kidney Int 72:985–993 (2007).

    Article  PubMed  CAS  Google Scholar 

  13. Liu, J., Qu, W. & Kadiiska, M. B. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol 238:209–214 (2009).

    Article  PubMed  CAS  Google Scholar 

  14. Oh, S. H. & Lim, S. C. A rapid and transient ROS generation by cadmium triggers apoptosis via caspasedependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation. Toxicol Appl Pharmacol 212:212–223 (2006).

    Article  PubMed  CAS  Google Scholar 

  15. Joseph, P. et al. Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun and c-myc proto-oncogenes: Role of cellular calcium and reactive oxygen species. Toxicol Sci 61:295–303 (2001).

    Article  PubMed  CAS  Google Scholar 

  16. Taneja, N. et al. Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy. J Biol Chem 279:2273–2280 (2004).

    Article  PubMed  CAS  Google Scholar 

  17. Fenech, M. The in vitro micronucleus technique. Mutat Res 455:81–95 (2000).

    Article  PubMed  CAS  Google Scholar 

  18. Filipic, M. & Hei, T. K. Mutagenicity of cadmium in mammalian cells: implication of oxidative DNA damage. Mutat Res 546:81–91 (2004).

    Article  PubMed  CAS  Google Scholar 

  19. Sachi, Y. et al. Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells. Immunol Lett 44:189–193 (1995).

    Article  PubMed  CAS  Google Scholar 

  20. Nakamura, H., Nakamura, K. & Yodoi, J. Redox regulation of cellular activation. Annu Rev Immunol 15:351–369 (1997).

    Article  PubMed  CAS  Google Scholar 

  21. Kumar, S. & Holmgren, A. Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters. Carcinogenesis 20:1761–1767 (1999).

    Article  PubMed  CAS  Google Scholar 

  22. Newairy, A. A. et al. The hepatoprotective effects of selenium against cadmium toxicity in rats. Toxicology 242:23–30 (2007).

    Article  PubMed  CAS  Google Scholar 

  23. Fenech, M. The micronucleus assay determination of chromosomal level DNA damage. Methods Mol Biol 410:185–216 (2008).

    Article  PubMed  CAS  Google Scholar 

  24. Biaglow, J. E. & Miller, R. A. The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy. Cancer Biol Ther 4:6–13 (2005).

    Article  PubMed  CAS  Google Scholar 

  25. Singh, N. P., McCoy, M. T., Tice, R. R. & Schneider, E. L. A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 171:184–191 (1988).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Life Science, Institute of Environmental Medicine for Green Chemistry, Dongguk University-Seoul, 30 Pildong-ro 1-gil (26 Pildong 3-ga), Jung-gu, Seoul, 100-715, Korea

    Jee Yeon Park, Preeyaporn Koedrith & Young Rok Seo

  2. Department of Pharmacology, School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Korea

    Jee Yeon Park

  3. Department of Biomedical Engineering, School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Korea

    Young Ju Lee

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  1. Jee Yeon Park
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  3. Preeyaporn Koedrith
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  4. Young Rok Seo
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Correspondence to Young Rok Seo.

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Park, J.Y., Lee, Y.J., Koedrith, P. et al. Protective role of thioredoxin reductase 1 in cadmium-induced DNA damage. Mol. Cell. Toxicol. 8, 289–295 (2012). https://doi.org/10.1007/s13273-012-0035-3

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  • DOI: https://doi.org/10.1007/s13273-012-0035-3

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