Abstract
As cells age, they lose their ability to properly fold proteins, maintain protein folding, and eliminate misfolded proteins, which leads to the accumulation of abnormal protein aggregates and loss of protein homeostasis (proteostasis). Loss of proteostasis can accelerate aging and the onset of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Mechanisms exist to prevent the detrimental effects of abnormal proteins that incorporate chaperones, autophagy, and the ubiquitin-proteasome system. These mechanisms are evolutionarily conserved across various species. Therefore, the effect of impaired proteostasis on aging has been studied using model organisms that are appropriate for aging studies. In this review, we focus on the relationship between proteostasis and aging, and factors that affect proteostasis in Drosophila. The manipulation of proteostasis can alter lifespan, modulate neurotoxicity, and delay the onset of neurodegeneration, indicating that proteostasis may be a novel pharmacological target for the development of treatments for various age-associated diseases.
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We apologize to the authors whose publications have not been cited due to space limitations. This research was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (Grant No. 2020R1A2B5B01098063). This research was supported by the Chung-Ang University Graduate Research Scholarship in 2019.
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Yu, G., Hyun, S. Proteostasis-associated aging: lessons from a Drosophila model. Genes Genom 43, 1–9 (2021). https://doi.org/10.1007/s13258-020-01012-9
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DOI: https://doi.org/10.1007/s13258-020-01012-9