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Influences of −482C>T and 3238G>C polymorphisms of the Apolipoprotein C3 gene on prevalence of metabolic syndrome

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Abstract

Apolipoprotein C3 (ApoC3) plays a regulatory role in triglyceride (TG) metabolism. The higher level of TG can be a cause in pathogenesis of the vascular diseases or metabolic syndrome (MetS). In this study, we examined the associations of ApoC3 polymorphisms (−482C>T rs2854117 and 3238G>C rs5128) with Korean MetS patients. A total of 835 subjects were investigated, including 320 patients with MetS and 515 healthy subjects. The genotype analysis of the ApoC3 polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism methods. Of the two polymorphisms studied, we observed a significant difference in the −482C>T polymorphism between the MetS and control groups. The TT genotype of the −482C>T polymorphism was associated with increased risk for MetS, compared with the controls (OR 1.627, 95 % CI 1.075–2.463, P = 0.021). The association was female-specific. No associations were found for the risk of MetS in the 3238G>C polymorphism. Haplotypes composed of two polymorphisms, however, were associated with MetS susceptibility in only male group. The 3238G>C polymorphism was significantly associated with TG levels (P = 0.013). Our data suggest that the ApoC3 −482C>T polymorphism is associated with increased MetS susceptibility in the Korean population.

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Acknowledgments

This work was supported by a research grant from Jeju National University Hospital in 2014.

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Authors and Affiliations

  1. Department of Laboratory Medicine, School of Medicine, Jeju National University, Jeju, 690-756, Republic of Korea

    Young Ree Kim

  2. Department of Science Education, Teachers College, Jeju National University, Jeju, 63294, Republic of Korea

    Seung-Ho Hong

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  1. Young Ree Kim
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Correspondence to Seung-Ho Hong.

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Written informed consent was approved by the Institutional Review Board of Jeju National University Hospital. The experimental procedures followed the standard regulation of the Review Board.

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Kim, Y.R., Hong, SH. Influences of −482C>T and 3238G>C polymorphisms of the Apolipoprotein C3 gene on prevalence of metabolic syndrome. Genes Genom 38, 857–864 (2016). https://doi.org/10.1007/s13258-016-0431-5

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