Abstract
Apolipoprotein A1 (ApoA1) plays an important role in reverse cholesterol transport. The functional abnormality of ApoA1 is known to be the major risk for lipid disorders or cardiovascular diseases. In this study, we examined the associations of two ApoA1 polymorphisms (XmnI and MspI/rs670) with the Korean patients with metabolic syndrome (MetS). A total of 835 subjects were investigated, which includes 320 patients with MetS and 515 healthy controls. Genotyping of the ApoA1 polymorphisms was analyzed by conventional polymerase chain reaction and digestions with restriction endonucleases. The mutant genotypes of the XmnI and MspI polymorphisms were associated with the decreased risk of MetS. The X1-A and X2-G haplotypes for the XmnI and MspI polymorphisms were also protective to susceptibility for MetS. The XmnI and MspI polymorphisms showed significant associations with DBP (P = 0.047) and body mass index (P = 0.037) among MetS risk factors, respectively. Stratified analysis for MetS risk components was significantly associated between the XmnI polymorphism and blood pressure. Based on these results, the variants and haplotypes of the ApoA1 polymorphisms may be protective against MetS susceptibility in Koreans.
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Acknowledgments
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2012R1A1A4A01012216).
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Written informed consent was approved by the Institutional Review Board of Jeju National University Hospital. The experimental procedures followed the standard regulation of the Review Board.
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Kim, Y.R., Hong, SH. The Apolipoprotein A1 polymorphisms were associated with decreased risk for metabolic syndrome in Koreans. Genes Genom 37, 875–882 (2015). https://doi.org/10.1007/s13258-015-0318-x
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DOI: https://doi.org/10.1007/s13258-015-0318-x