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Prognostic value of hepatoma-derived growth factor-related protein 3 (HRP-3) methylation in non-small cell lung cancer

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Abstract

Lung cancer is the leading cause of cancer deaths worldwide and is usually associated with a late diagnosis and a poor prognosis. Transcriptional silencing by CpG island hypermethylation has become a critical component in the initiation and progression of lung cancer. Hepatoma-derived growth factor (HDGF) is a nuclear targeted mitogen to be a potent tumorigenic and prognostic factor in cancers. To examine the clinical impaction of HDGF-related protein 3 (HRP-3) in lung cancer, we determined its methylation status in resected samples of primary non-small cell lung cancer (NSCLC) and evaluated the association with clinicopathologic characteristics. HRP-3 methylation was found in 35.1 % NSCLCs (73/208), which was significantly higher than 8.6 % of adjacent normal tissues. However, no association between HRP-3 expression level and methylation was found. Significantly higher methylation was found in adenocarcinoma (AC) without EGFR mutation than in AC with EGFR mutation. Univariate analysis revealed that HRP-3 methylation was associated with increased survival in total patients and defined subgroups including men, ever-smokers, and squamous cell carcinoma patients. Our data indicate that HRP-3 methylation could potentially be used as tissue-based prognostic markers in NSCLC. Further studies with large numbers of patients are needed to confirm the clinical significance of HRP-3 methylation.

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Acknowledgments

This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (Grant Number: HI4C0402).

Conflict of interest

The authors declare that they have no conflict of interest.

Compliance with ethical standards

All materials derived from the National Biobank of Korea - KNUH were obtained under institutional review board approved protocols.

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Authors and Affiliations

  1. Department of Anatomy and BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, 2-101 Dongin-dong, Jung-gu, Daegu, 702-422, Republic of Korea

    Young Hun Kim & Dong Sun Kim

  2. Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, 702-422, Republic of Korea

    Won Kee Lee

  3. Department of Internal Medicine, School of Medicine, Kyungpook National University, 2-101 Dongin-dong, Jung-gu, Daegu, 702-422, Republic of Korea

    Jae Yong Park

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  1. Young Hun Kim
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  2. Won Kee Lee
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Correspondence to Jae Yong Park or Dong Sun Kim.

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Kim, Y.H., Lee, W.K., Park, J.Y. et al. Prognostic value of hepatoma-derived growth factor-related protein 3 (HRP-3) methylation in non-small cell lung cancer. Genes Genom 37, 479–486 (2015). https://doi.org/10.1007/s13258-015-0277-2

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  • DOI: https://doi.org/10.1007/s13258-015-0277-2

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