Abstract
DNA methylation is an essential biochemical modification that regulates gene expression. Exercise induces changes in gene expression that adapt as metabolic changes in the blood. We provide a database for the epigenetic changes after horse exercise (http://www.primate.or.kr/hexdb). Horse Exercise Epigenetic Database (HExDB) explicates the change in genome-wide DNA methylation patterns after exercise. Exercise changes the genome-wide epigenetic patterns, and understanding the regions that change is important for confirming exercise physiological mechanisms. For this purpose, our database provides information on differentially methylated regions after exercise that pass a set threshold. A total of 784 genes based on NCBI RefSeq were identified as differentially methylated in equines after exercise. Our database provides clues for the study of exercise-related epigenetic pathways in the thoroughbred horse.
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Acknowledgments
This study was supported by a grant from the Next Generation BioGreen 21 Program (No. PJ0081062011), Rural Development Administration, Republic of Korea.
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The authors declare that they have no competing interests.
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Jeong-An Gim, Sugi Lee, Dae-Soo Kim contributed equally to this work.
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Gim, JA., Lee, S., Kim, DS. et al. HExDB: a database for epigenetic changes occurring after horse exercise. Genes Genom 37, 287–294 (2015). https://doi.org/10.1007/s13258-014-0251-4
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DOI: https://doi.org/10.1007/s13258-014-0251-4