Genes & Genomics

, Volume 35, Issue 4, pp 523–528 | Cite as

Porcine insulin-like growth factor 1 (IGF1) gene polymorphisms are associated with body size variation

  • Pengxia Niu
  • Sang-Wook Kim
  • Bong-Hwan Choi
  • Tae-Hun Kim
  • Jong-Joo Kim
  • Kwan-Suk Kim
Research Article


Previous studies have confirmed that insulin growth factor-1 (IGF1) plays important roles in growth and body size in humans and animals. However, whether single nucleotide polymorphisms (SNPs) within the IGF1 gene affects body size and growth in pigs has been unclear. We identified IGF1 SNPs among 5 pig breeds (Berkshire, Duroc, Landrace, Yorkshire and Korea Native Pig) and found that the G allele of SNP (c.G189A) was associated with higher body weight and was more predominant in western pig breeds, while the Korean Native Pig is the breed with the highest frequency of the A allele. Four haplotypes (–GA–, –GG–, –AG–, and –AA–) were constructed using the 2 identified SNPs. The GA haplotype was most frequently observed, except in the Berkshire breed. In addition, these SNPs and haplotypes were significantly associated with body size (final weight), average daily gain, and backfat thickness (P < 0.05) in 2 intercrossed F2 pig populations (KNP × YS F2 and KNP × LR F2). Furthermore, the major GA haplotype had a significant additive effect on body size and average daily gain. In conclusion, specific SNPs within the porcine IGF1 gene may contribute to the smaller body size and lower growth rate of Korea Native Pigs.


Carcass trait Growth trait IGF1 Pig SNP 



This work was supported by a grant entitled “Development of Genetic Improvement Systems in Pigs Using Genomic and Reproductive Technologies” from the Korea Institute of Planning and Evaluation for Technology of Food, Agriculture, Forestry and Fisheries.


  1. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263–265PubMedCrossRefGoogle Scholar
  2. Bian LH, Wang SZ, Wang QG, Zhang S, Wang YX, Li H (2008) Variation at the insulin-like growth factor 1 gene and its association with body weight traits in the chicken. J Anim Breed Genet 125:265–270PubMedCrossRefGoogle Scholar
  3. Boyko AR, Quignon P, Li L, Schoenebeck JJ, Degenhardt JD, Lohmueller KE, Zhao K, Brisbin A, Parker HG, vonHoldt BM et al (2010) A simple genetic architecture underlies morphological variation in dogs. PLoS Biol 8:e1000451PubMedCrossRefGoogle Scholar
  4. Choi TS, Park BY, Lee JM, Lee SK (2005) Comparison of carcass and meat quality characteristics between Korean native black pigs and commercial crossbred pigs. Korean J Food Sci Ani Resour 25:322–327Google Scholar
  5. Estany J, Tor M, Villalba D, Bosch L, Gallardo D, Jimenez N, Altet L, Noguera JL, Reixach J, Amills M et al (2007) Association of CA repeat polymorphism at intron 1 of insulin-like growth factor (IGF-I) gene with circulating IGF-I concentration, growth, and fatness in swine. Physiol Genomics 31:236–243PubMedCrossRefGoogle Scholar
  6. Kim EH, Choi BH, Kim KS, Lee CK, Cho BW, Kim TH, Kim JJ (2007) Detection of Mendelian and parent-of-origin quantitative trait loci in a cross between Korean native pig and Landrace I. Growth and body composition traits. Asian-Aust J Anim Sci 19:1702–1705Google Scholar
  7. Kim JJ, Lee HI, Park T, Kim K, Lee JE, Cho NH, Shin C, Cho YS, Lee JY, Han BG et al (2010) Identification of 15 loci influencing height in a Korean population. J Hum Genet 55:27–31PubMedCrossRefGoogle Scholar
  8. Kim SW, Li XP, Lee YM, Choi YI, Cho BW, Choi BH, Kim TH, Kim JJ, Kim KS (2011) QTL scan for meat quality traits using high-density SNP chip analysis in cross between Korean native pig and Yorkshire. Asian-Aust J Anim Sci 24:1184–1191CrossRefGoogle Scholar
  9. Li JQ, Chen ZM, Liu DW, Liu XH, Sun BL, Ling F, Zhang H, Chen YS (2003) Genetic effects of IGF-1 gene on the performance in Landrace × Lantang pig resource population. Yi Chuan Xue Bao 30:835–839PubMedGoogle Scholar
  10. Okada Y, Kamatani Y, Takahashi A, Matsuda K, Hosono N, Ohmiya H, Daigo Y, Yamamoto K, Kubo M, Nakamura Y et al (2010) A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. Hum Mol Genet 19:2303–2312PubMedCrossRefGoogle Scholar
  11. Reyna XF, Montoya HM, Castrellon VV, Rincon AM, Bracamonte MP, Vera WA (2010) Polymorphisms in the IGF1 gene and their effect on growth traits in Mexican beef cattle. Genet Mol Res 9:875–883PubMedCrossRefGoogle Scholar
  12. Silventoinen K, Magnusson PK, Tynelius P, Kaprio J, Rasmussen F (2008) Heritability of body size and muscle strength in young adulthood: a study of one million Swedish men. Genet Epidemiol 32:341–349PubMedCrossRefGoogle Scholar
  13. Stephens M, Smith N, Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978–989PubMedCrossRefGoogle Scholar
  14. Sutter NB, Bustamante CD, Chase K, Gray MM, Zhao K, Zhu L, Padhukasahasram B, Karlins E, Davis S, Jones PG et al (2007) A single IGF1 allele is a major determinant of small size in dogs. Science 316:112–115PubMedCrossRefGoogle Scholar
  15. Suzuki K, Nakagawa M, Katoh K, Kadowaki H, Shibata T, Uchida H, Obara Y, Nishida A (2004) Genetic correlation between serum insulin-like growth factor-1 concentration and performance and meat quality traits in Duroc pigs. J Anim Sci 82:994–999PubMedGoogle Scholar
  16. Tang S, Sun D, Ou J, Zhang Y, Xu G (2010) Evaluation of the IGFs (IGF1 and IGF2) genes as candidates for growth, body measurement, carcass, and reproduction traits in Beijing You and Silkie chickens. Anim Biotechnol 21:104–113PubMedCrossRefGoogle Scholar
  17. van Wijk HJ, Arts DJ, Matthews JO, Webster M, Ducro BJ, Knol EF (2005) Genetic parameters for carcass composition and pork quality estimated in a commercial production chain. J Anim Sci 83:324–333PubMedGoogle Scholar
  18. Wintero AK, Fredholm M, Andersson L (1994) Assignment of the gene for porcine insulin-like growth factor 1 (IGF1) to chromosome 5 by linkage mapping. Anim Genet 25:37–39PubMedGoogle Scholar
  19. Yang TL, Xiong DH, Guo Y, Recker RR, Deng HW (2008) Comprehensive association analyses of IGF1, ESR2, and CYP17 genes with adult height in Caucasians. Eur J Hum Genet 16:1380–1387PubMedCrossRefGoogle Scholar

Copyright information

© The Genetics Society of Korea 2013

Authors and Affiliations

  • Pengxia Niu
    • 1
  • Sang-Wook Kim
    • 1
  • Bong-Hwan Choi
    • 2
  • Tae-Hun Kim
    • 2
  • Jong-Joo Kim
    • 3
  • Kwan-Suk Kim
    • 1
  1. 1.Department of Animal ScienceChungbuk National UniversityCheongju-Si, ChungbukSouth Korea
  2. 2.Division of Animal Genomics and BioinformaticsNational Institute of Animal ScienceSuwonKorea
  3. 3.School of BiotechnologyYeungnam UniversityGyeongsanSouth Korea

Personalised recommendations