Porcine insulin-like growth factor 1 (IGF1) gene polymorphisms are associated with body size variation
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Previous studies have confirmed that insulin growth factor-1 (IGF1) plays important roles in growth and body size in humans and animals. However, whether single nucleotide polymorphisms (SNPs) within the IGF1 gene affects body size and growth in pigs has been unclear. We identified IGF1 SNPs among 5 pig breeds (Berkshire, Duroc, Landrace, Yorkshire and Korea Native Pig) and found that the G allele of SNP (c.G189A) was associated with higher body weight and was more predominant in western pig breeds, while the Korean Native Pig is the breed with the highest frequency of the A allele. Four haplotypes (–GA–, –GG–, –AG–, and –AA–) were constructed using the 2 identified SNPs. The GA haplotype was most frequently observed, except in the Berkshire breed. In addition, these SNPs and haplotypes were significantly associated with body size (final weight), average daily gain, and backfat thickness (P < 0.05) in 2 intercrossed F2 pig populations (KNP × YS F2 and KNP × LR F2). Furthermore, the major GA haplotype had a significant additive effect on body size and average daily gain. In conclusion, specific SNPs within the porcine IGF1 gene may contribute to the smaller body size and lower growth rate of Korea Native Pigs.
KeywordsCarcass trait Growth trait IGF1 Pig SNP
This work was supported by a grant entitled “Development of Genetic Improvement Systems in Pigs Using Genomic and Reproductive Technologies” from the Korea Institute of Planning and Evaluation for Technology of Food, Agriculture, Forestry and Fisheries.
- Choi TS, Park BY, Lee JM, Lee SK (2005) Comparison of carcass and meat quality characteristics between Korean native black pigs and commercial crossbred pigs. Korean J Food Sci Ani Resour 25:322–327Google Scholar
- Estany J, Tor M, Villalba D, Bosch L, Gallardo D, Jimenez N, Altet L, Noguera JL, Reixach J, Amills M et al (2007) Association of CA repeat polymorphism at intron 1 of insulin-like growth factor (IGF-I) gene with circulating IGF-I concentration, growth, and fatness in swine. Physiol Genomics 31:236–243PubMedCrossRefGoogle Scholar
- Kim EH, Choi BH, Kim KS, Lee CK, Cho BW, Kim TH, Kim JJ (2007) Detection of Mendelian and parent-of-origin quantitative trait loci in a cross between Korean native pig and Landrace I. Growth and body composition traits. Asian-Aust J Anim Sci 19:1702–1705Google Scholar