Skip to main content
SpringerLink
Log in

Lack of association between FOS polymorphisms and clearance of HBV infection as well as HCC occurrence

  • Research Article
  • Published:
Genes & Genomics Aims and scope Submit manuscript

Abstract

Human v-Fos Finuel-Biskis-Jinkins (FBJ) murine osteosarcoma viral oncogene homolog (FOS) is located in 14q24.3. The FOS protein is a constituent of the activating protein-1 (AP-1) and its increased expression in the hepatocellular carcinoma (HCC) have been reported. In this study, the association of FOS polymorphisms with the HBV infection and HCC occurrence were evaluated in Korean patients. After re-sequencing in 24 unrelated healthy individuals, two common single nucleotide polymorphisms (SNPs) in regulatory regions that were selected based on linkage disequilibrium were genotyped in a total of 1,093 Korean subjects including 656 HBV chronic carriers, who were further stratified into chronic hepatitis/liver cirrhosis (CH/LC, n = 339) and HCC (n = 317) groups, and 437 spontaneously recovered (SR) controls. Logistic regression and Cox relative hazard analysis showed no significant association of regulatory polymorphisms and haplotypes in FOS with HBV clearance and HCC development (P > 0.05, respectively).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Arbuthnot P, Kew M and Fitschen W (1991) c-fos and c-myc oncoprotein expression in human hepatocellular carcinomas. Anticancer Res. 11: 921–924.

    PubMed  CAS  Google Scholar 

  • Asim M, Malik A, Sarma MP, Polipalli SK, Begum N, Ahmad I, Khan LA, Husain SA, Akhtar N, Husain S, et al. (2010) Hepatitis B virus BCP, Precore/core, X gene mutations/genotypes and the risk of hepatocellular carcinoma in India. J. Med. Virol. 82: 1115–1125.

    Article  PubMed  CAS  Google Scholar 

  • Bosch FX, Ribes J, Cleries R and Diaz M (2005) Epidemiology of hepatocellular carcinoma. Clin. Liver. Dis. 9: 191–211.

    Article  PubMed  Google Scholar 

  • Boulling A, Le Gac G, Dujardin G, Chen JM and Ferec C (2010) The c.1275A>G putative chronic pancreatitis-associated synonymous polymorphism in the glycoprotein 2 (GP2) gene decreases exon 9 inclusion. Mol. Genet. Metab. 99: 319–324.

    Article  PubMed  CAS  Google Scholar 

  • Brinster RL, Allen JM, Behringer RR, Gelinas RE and Palmiter RD (1988) Introns increase transcriptional efficiency in transgenic mice. Proc. Natl. Acad. Sci. U S A 85: 836–840.

    Article  PubMed  CAS  Google Scholar 

  • Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, Christensen E, Pagliaro L, Colombo M and Rodes J (2001) Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J. Hepatol. 35: 421–430.

    Article  PubMed  CAS  Google Scholar 

  • Cheong JY, Cho SW, Oh B, Kimm K, Lee KM, Shin SJ, Lee JA, Park BL, Cheong HS, Shin HD, et al. (2010) Association of interleukin-18 gene polymorphisms with hepatitis B virus clearance. Dig. Dis. Sci. 55: 1113–1119.

    Article  PubMed  CAS  Google Scholar 

  • Chun JY, Bae JS, Park TJ, Kim JY, Park BL, Cheong HS, Lee HS, Kim YJ and Shin HD (2009) Putative association of DNA methyltransferase 1 (DNMT1) polymorphisms with clearance of HBV infection. BMB Rep. 42: 834–839.

    Article  PubMed  CAS  Google Scholar 

  • Durchdewald M, Angel P and Hess J (2009) The transcription factor Fos: a Janus-type regulator in health and disease. Histol. Histopathol. 24: 1451–1461.

    PubMed  CAS  Google Scholar 

  • Eberle MA and Kruglyak L (2000) An analysis of strategies for discovery of single-nucleotide polymorphisms. Genet. Epidemiol. 19Suppl 1: S29–S35.

    Article  PubMed  Google Scholar 

  • Eshima K, Fukaya S, Sugimoto A, Mori T, Yokoi H, Yamamoto Y, Sugiura S, Honda S, Masuko N, Murakami K, et al. (2009) Contribution of AP-1 interference induced by TAC-101 to tumor growth suppression in a hepatocellular carcinoma model. Tumour Biol. 30: 1–7.

    Article  PubMed  CAS  Google Scholar 

  • Guo LL, Xiao S and Guo Y (2005) Activation of transcription factors NF-kappaB and AP-1 and their relations with apoptosis associated-proteins in hepatocellular carcinoma. World J. Gastroenterol. 11: 3860–3865.

    PubMed  CAS  Google Scholar 

  • Hedrick PW (1987) Gametic disequilibrium measures: proceed with caution. Genetics 117: 331–341.

    PubMed  CAS  Google Scholar 

  • Kim LH, Shin HD, Park BL, Jung JH, Kim JY, Kim YJ and Lee HS (2003) Identification of variants in NFKBIA and association analysis with hepatocellular carcinoma risk among chronic HBV patients. Hum. Mutat. 21: 652–653.

    Article  PubMed  Google Scholar 

  • Kim LK, Choi UY, Cho HS, Lee JS, Lee WB, Kim J, Jeong K, Shim J, Kim-Ha J and Kim YJ (2007) Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. PLoS Biol. 5: e238.

    Article  PubMed  Google Scholar 

  • Kim T, Yoon J, Cho H, Lee WB, Kim J, Song YH, Kim SN, Yoon JH, Kim-Ha J and Kim YJ (2005) Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules. Nat. Immunol. 6: 211–218.

    Article  PubMed  CAS  Google Scholar 

  • Kim YJ, Yoon JH, Kim CY, Kim LH, Park BL, Shin HD and Lee HS (2006) IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma. Biochem. Biophys. Res. Commun. 346: 38–44.

    Article  PubMed  CAS  Google Scholar 

  • Kim YS, Cheong JY, Cho SW, Lee KM, Hwang JC, Oh B, Kimm K, Lee JA, Park BL, Cheong HS, et al. (2009) A functional SNP of the interleukin-18 gene is associated with the presence of hepatocellular carcinoma in hepatitis B virus-infected patients. Dig. Dis. Sci. 54: 2722–2728.

    Article  PubMed  CAS  Google Scholar 

  • Lee MS, Kim DH, Kim H, Lee HS, Kim CY, Park TS, Yoo KY, Park BJ and Ahn YO (1998) Hepatitis B vaccination and reduced risk of primary liver cancer among male adults: a cohort study in Korea. Int. J. Epidemiol. 27: 316–319.

    Article  PubMed  CAS  Google Scholar 

  • Li S, Fu H, Wang Y, Tie Y, Xing R, Zhu J, Sun Z, Wei L and Zheng X (2009) MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma. Hepatology 49: 1194–1202.

    Article  PubMed  CAS  Google Scholar 

  • Li YQ, Tao KS, Ren N and Wang YH (2005) Effect of c-fos antisense probe on prostaglandin E2-induced upregulation of vascular endothelial growth factor mRNA in human liver cancer cells. World J. Gastroenterol. 11: 4427–4430.

    PubMed  CAS  Google Scholar 

  • Liu P, Kimmoun E, Legrand A, Sauvanet A, Degott C, Lardeux B and Bernuau D (2002) Activation of NF-kappa B, AP-1 and STAT transcription factors is a frequent and early event in human hepatocellular carcinomas. J. Hepatol. 37: 63–71.

    Article  PubMed  Google Scholar 

  • Mahner S, Baasch C, Schwarz J, Hein S, Wolber L, Janicke F and Milde-Langosch K (2008) C-Fos expression is a molecular predictor of progression and survival in epithelial ovarian carcinoma. Br. J. Cancer 99: 1269–1275.

    Article  PubMed  CAS  Google Scholar 

  • Mason WS, Liu C, Aldrich CE, Litwin S and Yeh MM (2010) Clonal expansion of normal appearing human hepatocytes during chronic HBV infection. J. Virol. 84: 8308–8315.

    Article  PubMed  CAS  Google Scholar 

  • Menashe I, Rosenberg PS and Chen BE (2008) PGA: power calculator for case-control genetic association analyses. BMC Genet. 9: 36.

    Article  PubMed  Google Scholar 

  • Pagani F and Baralle FE (2004) Genomic variants in exons and introns: identifying the splicing spoilers. Nat. Rev. Genet. 5: 389–396.

    Article  PubMed  CAS  Google Scholar 

  • Park BL, Kim YJ, Cheong HS, Kim LH, Choi YH, Lee HS and Shin HD (2006) Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance. Exp. Mol. Med. 38: 694–702.

    PubMed  CAS  Google Scholar 

  • Park BL, Kim YJ, Cheong HS, Lee SO, Han CS, Yoon JH, Park JH, Chang HS, Park CS, Lee HS, et al. (2007) HDAC10 promoter polymorphism associated with development of HCC among chronic HBV patients. Biochem. Biophys. Res. Commun. 363: 776–781.

    Article  PubMed  CAS  Google Scholar 

  • Park TJ, Chun JY, Bae JS, Park BL, Cheong HS, Lee HS, Kim YJ and Shin HD (2010) CCND2 polymorphisms associated with clearance of HBV Infection. J. Hum. Genet. 55: 416–420.

    Article  PubMed  CAS  Google Scholar 

  • Ryder SD (2003) Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults. Gut 52 Suppl 3: iii1–iii8.

    Google Scholar 

  • Shin HD, Park BL, Cheong HS, Yoon JH, Kim YJ and Lee HS (2007) SPP1 polymorphisms associated with HBV clearance and HCC occurrence. Int. J. Epidemiol. 36: 1001–1008.

    Article  PubMed  Google Scholar 

  • Shin HD, Park BL, Kim LH, Jung JH, Kim JY, Yoon JH, Kim YJ and Lee HS (2003) Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma. Hum. Mol. Genet. 12: 901–906.

    Article  PubMed  CAS  Google Scholar 

  • Stephens M, Smith NJ and Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68: 978–989.

    Article  PubMed  CAS  Google Scholar 

  • Thursz M (2001) Genetic susceptibility in chronic viral hepatitis. Antiviral Res. 52: 113–116.

    Article  PubMed  CAS  Google Scholar 

  • Wang Z, Xiang Q, Li D and Li S (1991) Correlation between gene expression and chromatin conformation of c-fos and N-ras in human liver and hepatoma. Chin. Med. Sci. J. 6: 6–8.

    PubMed  CAS  Google Scholar 

  • Xiangji L, Feng X, Qingbao C, Weifeng T, Xiaoqing J, Baihe Z, Feng S, Hongyang W and Mengchao W (In press) Knockdown of HBV surface antigen gene expression by a lentiviral microRNA-based system inhibits HBV replication and HCC growth. J. Viral. Hepat. DOI: 10.1111/j.1365-2893.2010.01346.x.

  • Yuen MF, Wu PC, Lai VC, Lau JY and Lai CL (2001) Expression of c-Myc, c-Fos, and c-jun in hepatocellular carcinoma. Cancer 91: 106–112.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Life Science, Sogang University, 1 Shinsu-dong, Mapo-gu, Seoul, 121-742, Korea

    Tae-Joon Park, Jeong-Hyun Kim, Joon Seol Bae, Charisse Flerida Pasaje & Hyoung Doo Shin

  2. Department of Genetic Epidemiology, SNP Genetics, Inc., 1407 14th Floor, Woolim lion’s valley B, Gasan-dong, Geumcheon-gu, Seoul, 153-803, Korea

    Byung-Lae Park, Hyun Sub Cheong & Hyoung Doo Shin

  3. Department of Internal Medicine and Liver Research Institute, Seoul National University, College of Medicine, 28 Yungun-dong, Chongro-gu, Seoul, 110-744, Korea

    Hyo Suk Lee & Yoon Jun Kim

Authors
  1. Tae-Joon Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jeong-Hyun Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Byung-Lae Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Joon Seol Bae
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hyun Sub Cheong
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Charisse Flerida Pasaje
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hyo Suk Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yoon Jun Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hyoung Doo Shin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yoon Jun Kim or Hyoung Doo Shin.

Additional information

The first two authors, TJP and JHK, contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Park, TJ., Kim, JH., Park, BL. et al. Lack of association between FOS polymorphisms and clearance of HBV infection as well as HCC occurrence. Genes Genom 33, 327–333 (2011). https://doi.org/10.1007/s13258-010-0179-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13258-010-0179-2

Keywords

Search

Navigation