Monte Carlo simulations for dose enhancement in cancer treatment using bismuth oxide nanoparticles implanted in brain soft tissue
The objective of this work is to study the dosimetric performances of bismuth oxide nanoparticles implanted in tumors in cancer radiotherapy. GEANT4 based Monte Carlo numerical simulations were performed to assess dose enhancement distributions in and around a 1 × 1 × 1 cm3 tumor implanted with different concentrations of bismuth oxide and irradiated with low energies 125I, 131Cs, and 103Pd radioactive sources. Dose contributions were considered from photoelectrons, Auger electrons, and characteristic X-rays. Our results show the dose enhancement increased with increasing both bismuth oxide concentration in the target and photon energy. A dose enhancement factor up to 18.55 was obtained for a concentration of 70 mg/g of bismuth oxide in the tumor when irradiated with 131Cs source. This study showed that bismuth oxide nanoparticles are innovative agents that could be potentially applicable to in vivo cancer radiotherapy due to the fact that they induce a highly localized energy deposition within the tumor.
KeywordsGamma-ray Bismuth Nanoparticles Dose enhancement
Compliance with ethical standards
Conflict of interest
All authors declares that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
- 16.Alqathami M, Blencowe A, Yeo UJ, Franich R, Doran S, Qiao G et al (2013) Enhancement of radiation effects by bismuth oxide nanoparticles for kilovoltage X-ray beams: a dosimetric study using a novel multi-compartment 3D radiochromic dosimeter. J Phys 444:12025. https://doi.org/10.1088/1742-6596/444/1/012025 Google Scholar
- 17.Zhang X-W, Xia J, Yan H-W, Luo S-L, Yin S-F, Au C-T et al (2009) Synthesis, structure, and in vitro antiproliferative activity of cyclic hypervalent organobismuth(III) chlorides and their triphenylgermylpropionate derivatives. J Organomet Chem 694:3019–3026. https://doi.org/10.1016/j.jorganchem.2009.05.003 CrossRefGoogle Scholar
- 23.Stewart C, Konstantinov K, Mckinnon S, Guatelli S, Lerch M, Rosenfeld A et al (2016) Physica medica first proof of bismuth oxide nanoparticles as efficient radiosensitisers on highly radioresistant cancer cells. Phys Med 32:1444–1452. https://doi.org/10.1016/j.ejmp.2016.10.015 CrossRefPubMedGoogle Scholar
- 34.Gual MR, Cardona CMA, González LYC, García JR (2009) Use of nanoparticles in brachytherapy: an alternative for enhancing doses in cancer treatment. In World Congress on Medical Physics and Biomedical Engineering, Munich, pp 544–547. https://doi.org/10.1007/978-3-642-03474-9_153