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Comparison of dosimetry between PET/CT and PET alone using 11C-ITMM

  • Kimiteru ItoEmail author
  • Muneyuki Sakata
  • Keiichi Oda
  • Kei Wagatsuma
  • Jun Toyohara
  • Kenji Ishibashi
  • Kenji Ishii
  • Kiichi Ishiwata
Scientific Paper

Abstract

We used a new tracer, N-[4-[6-(isopropylamino) pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-11C-methoxy-N-methylbenzamide (11C-ITMM), to compare radiation doses from positron emission tomography (PET)/computed tomography (CT) with previously published doses from PET alone. Twelve healthy volunteers [six males (mean age ± SD, 27.7 ± 6.7 years) and six females (31.8 ± 14.5 years)] in 12 examinations were recruited. Dose estimations from PET/CT were compared with those from PET alone. Regions of interest (ROIs) in PET/CT were delineated on the basis of low-dose CT (LD-CT) images acquired during PET/CT. Internal and external radiation doses were estimated using OLINDA/EXM 1.0 and CT-Expo software. The effective dose (ED) for 11C-ITMM calculated from PET/CT was estimated to be 4.7 ± 0.5 μSv/MBq for the male subjects and 4.1 ± 0.7 μSv/MBq for the female subjects. The mean ED for 11C-ITMM calculated from PET alone in a previous report was estimated to be 4.6 ± 0.3 μSv/MBq (males, n = 3). The ED values for 11C-ITMM calculated from PET/CT in the male subjects were almost identical to those from PET alone. The absorbed doses (ADs) of the gallbladder, stomach, red bone marrow, and spleen calculated from PET/CT were significantly different from those calculated from PET alone. The EDs of 11C-ITMM calculated from PET/CT were almost identical to those calculated from PET alone. The ADs in several organs calculated from PET/CT differed from those from PET alone. LD-CT images acquired during PET/CT may facilitate organ identification.

Keywords

Radiation dosimetry PET/CT PET Biodistribution 11C-ITMM 

Notes

Acknowledgments

No potential conflicts of interest were disclosed. This work was supported by a Grant-in-Aid for Scientific Research (B), No. 24390298, from The Japan Society for the Promotion of Science. We thank Kumpei Hayashi, Airin Oonishi, and Hatsumi Endo for their technical assistance.

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Copyright information

© Australasian College of Physical Scientists and Engineers in Medicine 2015

Authors and Affiliations

  • Kimiteru Ito
    • 1
    • 2
    Email author
  • Muneyuki Sakata
    • 2
  • Keiichi Oda
    • 2
    • 3
  • Kei Wagatsuma
    • 2
  • Jun Toyohara
    • 2
  • Kenji Ishibashi
    • 2
  • Kenji Ishii
    • 2
  • Kiichi Ishiwata
    • 2
  1. 1.Department of Diagnostic RadiologyTokyo Metropolitan Geriatric Hospital and Institute of GerontologyTokyoJapan
  2. 2.Research Team for NeuroimagingTokyo Metropolitan Institute of GerontologyTokyoJapan
  3. 3.Department of Radiological Technology, Faculty of Health SciencesHokkaido University of ScienceSapporoJapan

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