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Cardiovascular Engineering and Technology

, Volume 9, Issue 3, pp 503–513 | Cite as

Fabrication and Testing of Electrospun Polyurethane Blended with Chitosan Nanoparticles for Vascular Graft Applications

  • Ranjeeta Subramaniam
  • Mohan Prasath Mani
  • Saravana Kumar JaganathanEmail author
Article
  • 183 Downloads

Abstract

In this study, a small vascular graft based on polyurethane (PU) blended with chitosan (Ch) nanoparticles was fabricated using electrospinning technique. Initially, the chitosan nanoparticles were synthesized using ionic gelation method. UV–Vis spectrophotometer confirmed the presence of synthesized Ch nanoparticles by exhibiting absorption peak at 288 nm and the Fourier-transform infrared spectroscopy (FTIR) analysis confirmed the existence of the chitosan. Further, the synthesized Ch nanoparticles showed size diameter in the range of 134 ± 58 nm as measured using ImageJ. In the electrospun PU/chitosan graft, the fiber diameter and pore size diameter was found to be reduced compared to the pure PU owing to incorporation of chitosan into PU matrix. The FTIR spectrum revealed the presence of chitosan in the prepared nanocomposite membrane by the formation of the hydrogen bond and peak shift of CH and NH stretching. Moreover, the contact angle measurements revealed that the prepared graft showed decreased contact angle indicating hydrophilic nature compared to the pristine PU. The cytocompatibility studies revealed the non-toxic behavior of the fabricated graft. Hence, the prepared graft exhibiting significant physiochemical and non-toxic properties may be a plausible candidate for cardiovascular graft applications.

Keywords

Polyurethane/chitosan membrane Ionic gelation method Electrospinning Physiochemical characterization Vascular graft 

Notes

Funding

This work was supported by the Ministry of Higher Education Malaysia with the Grant Number Q.J130000.2545.14H59.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Biomedical Engineering Society 2018

Authors and Affiliations

  1. 1.Faculty of Biosciences and Medical EngineeringUniversiti Teknologi MalaysiaSkudaiMalaysia
  2. 2.Department for Management of Science and Technology DevelopmentTon Duc Thang UniversityHo Chi Minh CityVietnam
  3. 3.Faculty of Applied SciencesTon Duc Thang UniversityHo Chi Minh CityVietnam
  4. 4.IJN-UTM Cardiovascular Engineering Centre, Department of Clinical Sciences, Faculty of Biosciences and Medical EngineeringUniversiti Teknologi MalaysiaSkudaiMalaysia

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