Abstract
Ig superfamily (IgSF) constitutes the largest superfamily in human genome. In particular, Ig-like domains are the most abundant structural module within cell surface receptors, functioning in nervous as well as immune system. Here I describe some key sequence signature of an I-set Ig-like domain from known structures of IgSF members. These signature residues define the I-set Ig-like domain, which should aid structural and functional studies of cell surface receptors.
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Wang, JH. The sequence signature of an Ig-fold. Protein Cell 4, 569–572 (2013). https://doi.org/10.1007/s13238-013-3903-2
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DOI: https://doi.org/10.1007/s13238-013-3903-2