Protein & Cell

, Volume 1, Issue 8, pp 711–717 | Cite as

Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma

  • Takuma HayashiEmail author
  • Akiko Horiuchi
  • Kenji Sano
  • Nobuyoshi Hiraoka
  • Yae Kanai
  • Tanri Shiozawa
  • Susumu Tonegawa
  • Ikuo Konishi


Uterine tumors are the most common type of gynecologic neoplasm. Uterine leiomyosarcoma (LMS) is rare, accounting for 2% to 5% of tumors of the uterine body. Uterine LMS develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Radiographic evaluation combined with PET/CT can be useless in the diagnosis and surveillance of uterine LMS. Importantly, a diagnostic biomarker, which distinguishes malignant LMS and benign tumor leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS in order to establish a method of treatment. LMP2-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ∼40% by 14 months of age. It is therefore of interest whether human uterine LMS shows a loss of LMP2 expression. We found LMP2 expression is absent in human LMS, but present in human LMA. Therefore, defective LMP2 expression may be one of the risk factors for LMS. LMP2 is potentially a diagnostic biomarker for uterine LMS, and gene therapy with LMP2-encording DNA may be a new therapeutic approach.


LMP2 uterine leiomyosarcoma uterine leiomyoma diagnostic biomarker 


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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Takuma Hayashi
    • 1
    • 7
    Email author
  • Akiko Horiuchi
    • 2
  • Kenji Sano
    • 3
  • Nobuyoshi Hiraoka
    • 4
  • Yae Kanai
    • 4
  • Tanri Shiozawa
    • 2
  • Susumu Tonegawa
    • 5
  • Ikuo Konishi
    • 6
  1. 1.Department of Immunology and Infectious DiseaseShinshu University Graduate School of MedicineMatsumoto, NaganoJapan
  2. 2.Department of Obstetrics and GynecologyShinshu University School of MedicineMatsumoto, NaganoJapan
  3. 3.Department of Laboratory MedicineShinshu University HospitalMatsumoto, NaganoJapan
  4. 4.Pathology DivisionNational Cancer Center Research InstituteTokyoJapan
  5. 5.Picower Institution and Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA
  6. 6.Department of Obstetrics and GynecologyKyoto University Graduate School of MedicineSakyo-ku, KyotoJapan
  7. 7.Promoting Business using Advanced TechnologyJapan Science and Technology Agency (JST)Kawaguchi-shi, SaitamaJapan

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