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Performance Improvement of Hydrophobized Bacterial Cellulose Films as Wound Dressing

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Abstract

In the wound dressing research field, there is a continuous search for high-quality materials which present properties superior to those already used. Bacterial cellulose films are recognized as being effective, but their performance can still be further enhanced. On the other hand, wound dressings which present surfaces modified with hydrophobic molecules, such as dialkyl carbamoyl chloride, appear to be an alternative material, acting as antimicrobial dressings. Based on that, this paper describes the synthesis of small hydrophobic molecules based on inexpensive alcohols, such as octyl and benzyl alcohol, conjugated to the hydroxyl groups of bacterial cellulose. The films were prepared using ultrasound irradiation and characterized via infrared, as well as for their wettability and water absorption capacity, which showed greater contact angles and similar moisture retention when compared to unmodified films. Morphological aspects of modified films were analyzed by scanning electron microscope (SEM) and minimal modification in the structure was found. The hydrophobized cellulose films showed cytocompatibility with fibroblasts, and antimicrobial activity when compared to native bacterial cellulose films, by reducing the bacterial load up to 75%. This type of modification on these films is of interest in order to prepare films with better properties as dressings based on bacterial cellulose.

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Authors and Affiliations

  1. Programa de Pós-graduação em Ciência e Engenharia de Materiais (PPGCEM), Universidade Tecnológica Federal do Paraná, UTFPR-Ld, CEP, 86036-370, Londrina, PR, Brazil

    Katlyn Bazoli dos Santos & Renato Márcio Ribeiro-Viana

  2. Departamento Acadêmico de Química, Universidade Tecnológica Federal do Paraná, UTFPR-Ld, CEP, 86036-370, Londrina, PR, Brazil

    Gustavo Eiji Higawa, Alessandra Stevanato & Renato Márcio Ribeiro-Viana

  3. Departamento de Bioquímica e Biotecnologia, Universidade Estadual de Londrina, UEL, CEP 86051-980, Londrina, PR, Brazil

    Karen Stefany Conceição & Cesar Augusto Tischer

  4. Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Vila Velha — UVV, CEP 29102-920, Vila Velha, ES, Brazil

    Denise Coutinho Endringer, Elisangela Flavia Pimentel Schmitt, Lorena Martins Xavier & Marcio Fronza

Authors
  1. Katlyn Bazoli dos Santos
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  2. Gustavo Eiji Higawa
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  3. Karen Stefany Conceição
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  4. Denise Coutinho Endringer
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  9. Cesar Augusto Tischer
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  10. Renato Márcio Ribeiro-Viana
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Correspondence to Renato Márcio Ribeiro-Viana.

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The data of this work were deposited in the form of a patent by the authors and institutions under the number BR 10 2020 020709 1.

Supporting Information

Information is available on the 13C and IR characterization of the synthesized molecules, in addition to the IR spectrum of the films that were reacted under conditions of absence of DIC coupling agent. The materials are available via the Internet at http://www.springer.com/13233.

Acknowledgment: The authors would like to thank the Spectroscopy Laboratory at the State University of Londrina (SPEC-UEL-CT INFRA 2009-01.10.0534.01), the Multiuser Laboratory at the Federal University of Technology — Paraná — Londrina campus — for the analyses performed and Scanning Electron Microscopy Laboratory at State University of Maringa (Dr Eduardo Radovanovic). The authors would also like to acknowledge the financial support received from CNPq — Brazilian National Counsel of Technological and Scientific Development (423643/2018-5), CAPES and Araucária Foundation for Scientific and Technological Development of Paraná State.

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dos Santos, K.B., Higawa, G.E., Conceição, K.S. et al. Performance Improvement of Hydrophobized Bacterial Cellulose Films as Wound Dressing. Macromol. Res. 30, 116–123 (2022). https://doi.org/10.1007/s13233-022-0005-0

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  • DOI: https://doi.org/10.1007/s13233-022-0005-0

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