Abstract
Chalcones are hydrophobic polyphenols with poor aqueous solubility. In this study, we prepared a new aspirin-conjugated chalcone derivative-loaded nanoparticle (AS-DK143-loaded NP) using mPEG-PLA co-polymer which, in an aqueous environment, spontaneously forms a micellar formulation with an average particle size of 22.55 nm. Exposure to varying concentrations of AS-DK143 NP significantly diminished the cell viability of 4T1 cells in a concentration-dependent manner. In tumor regression and biodistribution studies in 4T1-luc cell bearing mice, AS-DK143 NPs were shown to selectively target cancer cells and significantly reduce tumor size. These properties suggest anti-cancer efficacy, combined with low toxicity to healthy tissues, indicating a potential role as a safer alternative to currently available chemotherapy agents.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
N. Azamjah, Y. Soltan-Zadeh, and F. Zayeri, Asian Pac. J. Cancer Prev., 20, 2015 (2019).
D. R. Youlden, S. M. Cramb, C. H. Yip, and P. D. Baade, Cancer Biol Med., 11, 101 (2014).
W. Lorizio, A. H. Wu, M. S. Beattie, H. Rugo, S. Tchu, K. Kerlikowske and E. Ziv, Breast Cancer Res. Treat., 132, 1107 (2012).
X. Chen, M. Lowe, T. Herliczek, M. J. Hall, C. Danes, D. A. Lawrence, and K. Keyomarsi, J. Natl. Cancer Inst., 92, 1999 (2000).
S. Senapati, A. K. Mahanta, S. Kumar, and P. Maiti, Signal Transduct. Target. Then, 3, 7 (2018).
D. H. Lee, Y. J. Jung, D. Koh, Y. Lim, Y. H. Lee, and S. Y. Shin, Cancer Lett., 372, 1 (2016).
S. Kalepu and V. Nekkanti, Acta Pharm. Sin. B, 5, 442 (2015).
A. Undas, K. E. Brummel-Ziedins, and K. G. Mann, Blood, 109, 2285 (2007).
Boutaud, I. R. Sosa, T. Amin, D. Oram, D. Adler, H. S. Hwang, B. C. Crews, G. Milne, B. K. Harris, M. Hoeksema, B. C. Knollmann, P. E. Lammers, L. J. Marnett, P. P. Massion, and J. A. Oates, Cancer Prev. Res., 9, 855 (2016).
O. C. Sostres, C. J. Gargallo, and A. Lanas, World J. Gastrointest. Pharmacol. Ther., 5, 40 (2014).
Y. I. Kim, S. Y. Kim, J. H. Kim, J. H. Lee, Y. W. Kim, K. W. Ryu, J. H. Park, and I. J. Choi, Cancer Res. Treat., 48, 798 (2016).
W. Hao, Y. Shen, M. Feng, H. Wang, M. Lin, Y. Fang, and L. Tan, J. Thorac. Dis., 10, 2490 (2018).
S. Y. Shin, J. M. Lee, M. S. Lee, D. S. Koh, H. R. Jung, Y. H. Lim, and Y. H. Lee, Clin. Cancer Res., 20, 4302 (2014).
Y. S. Bae, H. Oh, S. G. Rhee, and Y. D. Yoo, Mol. Cells, 32, 491 (2011).
V. Aggarwal, H. S. Tuli, A. Varol, F. Thakral, M. B. Yerer, K. Sak, M. Varol, A. Jain, M. A. Khan, and G. Sethi, Biomolecules, 9, 735 (2019).
J. M. Matés and F. M. Sánchez-Jiménez, Int. J. Biochem. Cell Biol., 32, 157 (2000).
Y. Q. Zang, Y. Y. Feng, Y. H. Luo, Y. Q. Zhai, X. Y. Ju, Y. C. Feng, Y. N. Sheng, J. R. Wang, C. Q. Yu, and C. H. Jin, Mol. Med. Rep., 20, 4576 (2019).
H. Zhu, L. Tang, C. Zhang, B. Wei, P. Yang, D. He, L. Zheng, and Y. Zhang, Front. Pharmacol., 10, 1341 (2019).
L. D. Lavis, ACS Chem. Biol., 3, 203 (2008).
Y. Mao, Y. Zhang, Z. Luo, R. Zhan, H. Xu, W. Chen, and H. Huang, Molecules, 23, 3211 (2018).
F. A. Fisusi and E. O. Akala, Pharm. Nanotechnol., 7, 3 (2019).
W. Xu, P. Ling, and P. Zhang, J. Drug Deliv., 2013, 340315 (2013).
Y. J. Kim, K. P. Lee, D. Y. Lee, Y. T. Kim, D. Koh, Y. Lim, and M. S. Yoon, Macromol. Res., 27, 48 (2019).
Acknowledgment
This research was supported by the Korea Basic Science Institute (D010730).
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Lee, D.Y., Lee, K.P., Beak, S. et al. Antibreast Cancer Activity of Aspirin-Conjugated Chalcone Polymeric Micelles. Macromol. Res. 29, 105–110 (2021). https://doi.org/10.1007/s13233-021-9010-y
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13233-021-9010-y