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Phosphate-Functionalized Stabilized F127 Nanoparticles: Introduction of Discrete Surface Charges and Electrophoretic Determination of Aggregation Number

  • Juyoung Hwang
  • Mingyeong Kang
  • Mila Irva Sari
  • Tae Hyeong Lee
  • Kibeom Kim
  • Yeol Kyo Choi
  • Eunji Lee
  • Ja-Hyoung Ryu
  • Seung Ki Baek
  • Dong June Ahn
  • Peter C. W. LeeEmail author
  • Minseok KwakEmail author
Article
  • 38 Downloads

Abstract

Pluronic F127 forms spherical micelle with a defined number of molecules aggregated in aqueous environments. Such self-assembled micelles dissociate into unimers below certain concentration and temperature. We stabilized the micelles by semi-interpenetrating network (sIPN) formation within the hydrophobic core in the presence of a fluorescent dye. Additionally, by varying the mixing ratio of negatively charged and pristine F127s we prepared thermally stable polymeric nanoparticles with discrete surface charges within nearly same sizes. Using the nanomaterials with prescribed number of charges, we demonstrate that the electrophoretic mobility of nanoparticles is solely depending on number of surface charges. Finally, the aggregation number (Nagg) of F127 was further determined by electrophoresis.

Keywords

self-assembly encapsulation polymer aggregates Pluronic sIPNs 

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Copyright information

© The Polymer Society of Korea and Springer 2019

Authors and Affiliations

  • Juyoung Hwang
    • 1
  • Mingyeong Kang
    • 1
  • Mila Irva Sari
    • 1
  • Tae Hyeong Lee
    • 2
  • Kibeom Kim
    • 3
  • Yeol Kyo Choi
    • 4
  • Eunji Lee
    • 5
  • Ja-Hyoung Ryu
    • 3
  • Seung Ki Baek
    • 6
  • Dong June Ahn
    • 4
  • Peter C. W. Lee
    • 2
    Email author
  • Minseok Kwak
    • 1
    Email author
  1. 1.Department of ChemistryMarine-Integrated Bionics Research Center, Pukyong National UniversityBusanKorea
  2. 2.Department of Biomedical SciencesUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulKorea
  3. 3.Department of ChemistryUlsan National Institute of Science and Technology (UNIST)UlsanKorea
  4. 4.Department of Chemical and Biological EngineeringKorea UniversitySeoulKorea
  5. 5.School of Materials Science and EngineeringGwangju Institute of Science and Technology (GIST)GwangjuKorea
  6. 6.Department of PhysicsPukyong National UniversityBusanKorea

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