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Nanoparticles Based on Poly(trimethylene carbonate) Triblock Copolymers with Post-Crystallization Ability and Their Degradation in vitro

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Abstract

Aliphatic polycarbonate-based block copolymers have received considerable attention as carriers for targeted drug and gene delivery because of their biocompatibility and biodegradability. However, there is little understanding of their phase behaviour and physicochemical characterization of the particles made from them. Here, we prepared a series of well-defined poly(trimethylene carbonate) (PTMC)-based copolymers with molar masses of 3–9 kg·mol-1 by metal-free ring-opening polymerization using dihydroxy-terminated poly(ethylene oxide) as a macroinitiator. Micellar nanoparticles self-assembled from copolymers had a size of less than 130 nm. They were degraded by the action of a model lipase from Mucor Miehei at 37 °C, which is of high importance for biodegradability in the living organism. X-ray diffraction and differential scanning calorimetry proved that amorphous copolymers with more than 39 mol% of carbonate units and representative particles were prone to the rearrangement of PTMC chains during storage and to thus undergo post-crystallization. Our findings can contribute to the comprehensive characterization of polycarbonate biomaterials for medical applications.

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Authors and Affiliations

  1. Department of Polymers, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628, Prague, Czech Republic

    Lucie Reinišová & Soňa Hermanová

  2. Center for the Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 16628, Prague, Czech Republic

    Filip Novotný & Martin Pumera

  3. Faculty Hospital Kralovské Vinohrady, Center of Applied Bioimplantology, Šrobárova 50, Prague 10, 10043, Prague, Czech Republic

    Katarína Kološtová

Authors
  1. Lucie Reinišová
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  2. Filip Novotný
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  3. Martin Pumera
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  4. Katarína Kološtová
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  5. Soňa Hermanová
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Corresponding author

Correspondence to Soňa Hermanová.

Additional information

Acknowledgment: This work was supported by the project Advanced Functional Nanorobots (reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR) and from specific university research (MSMT No 21-SVV/2018).

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Reinišová, L., Novotný, F., Pumera, M. et al. Nanoparticles Based on Poly(trimethylene carbonate) Triblock Copolymers with Post-Crystallization Ability and Their Degradation in vitro. Macromol. Res. 26, 1026–1034 (2018). https://doi.org/10.1007/s13233-019-7007-6

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  • DOI: https://doi.org/10.1007/s13233-019-7007-6

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