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Anticancer Activity of a New Chalcone Derivative-Loaded Polymeric Micelle

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Abstract

Chalcones are hydrophobic polyphenols with extremely poor aqueous solubility. In this study, we prepared a new chalcone derivative-loaded nanoparticle (DPP-23-loaded NP) using a monomethoxy poly(ethylene glycol)-poly(D,L-lactide) copolymer which, in an aqueous environment, spontaneously forms a micellar formation with an average particle size of 20.8 nm. Exposure to various concentrations of DPP-23-loaded NP significantly diminished the cell viability of MCF-7 and MDA-MB-231 cells in a concentration-dependent manner. Our data show that DPP-23-loaded NP is a reliable drug delivery system, as observed by the fluorescein isothiocyanate (FITC) intensity accumulation in MDA-MB-231 cells.

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Author notes

  1. These authors equally contributed to this work.

Authors and Affiliations

  1. Department of Pharmaceutical Engineering, Hoseo University, Asan, Chungnam, 31499, Korea

    Young Jin Kim, Do Young Lee, Yun Tae Kim & Myeong Sik Yoon

  2. The Research Institute for Basic Sciences, Hoseo University, Asan, Korea

    Myeong Sik Yoon

  3. Department of Medical Science, School of Medicine, Konkuk University, Seoul, 05029, Korea

    Kang Pa Lee

  4. Department of Applied Chemistry, Dongduk Women’s University, Seoul, 02748, Korea

    Dongsoo Koh

  5. Division of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Korea

    Yoongho Lim

Authors
  1. Young Jin Kim
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  2. Kang Pa Lee
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  3. Do Young Lee
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  4. Yun Tae Kim
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  5. Dongsoo Koh
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  7. Myeong Sik Yoon
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Correspondence to Myeong Sik Yoon.

Additional information

Acknowledgment: This research was supported by the academic research fund of Hoseo University in 2014 (2014-0454).

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Kim, Y.J., Lee, K.P., Lee, D.Y. et al. Anticancer Activity of a New Chalcone Derivative-Loaded Polymeric Micelle. Macromol. Res. 27, 48–54 (2019). https://doi.org/10.1007/s13233-019-7002-y

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  • DOI: https://doi.org/10.1007/s13233-019-7002-y

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