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Graft Copolymerization of 2-Hydroxyethyl Methacrylate onto Chitosan Using Radiation Technique for Release of Diclofenac

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Abstract

Chitosan (CS) was modified with 2-hydroxyethyl methacrylate (HEMA) by gamma radiation to improve its water absorption ability and use it as a drug delivery system. For this, HEMA was grafted by direct method onto dissolved CS (homogeneous) or powder CS (heterogeneous) using doses less than 20 kGy. The grafting percentage was easily controlled changing the homogeneity of system. Low and medium grafting percentages (20-70%) were obtained with the heterogeneous method, while the homogeneous method yielded higher grafting percentages (~340%). CS-g-HEMA was confirmed using infrared spectroscopy (ATR-FTIR), thermogravimetric analyses (TGA) and X-ray diffraction (XRD). In addition, the swelling behaviour, critical pH, and drug absorption, using diclofenac as a model, were also evaluated. Results show that the presence of HEMA had a positive effect on swelling and the drug uptake when low grafting percentages were used; CS-g-HEMA (17%) swelled in water (261%) and loaded better amounts of diclofenac (1.5 mg g-1) than CS (0.97 mg g-1).

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Authors and Affiliations

  1. School of Chemistry, University of Bristol, Cantock’s Close, Bristol, BS8 1TS, UK

    Luisa Islas

  2. Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, Ciudad de México, México

    Guillermina Burillo & Alejandra Ortega

Authors
  1. Luisa Islas
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  2. Guillermina Burillo
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  3. Alejandra Ortega
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Correspondence to Alejandra Ortega.

Additional information

Acknowledgments: This work was supported by DGAPA UNAM IN200116. The authors thank F. Garcia, B. Leal, and M. Cruz of ICN-UNAM for their technical assistance.

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Islas, L., Burillo, G. & Ortega, A. Graft Copolymerization of 2-Hydroxyethyl Methacrylate onto Chitosan Using Radiation Technique for Release of Diclofenac. Macromol. Res. 26, 690–695 (2018). https://doi.org/10.1007/s13233-018-6100-6

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  • DOI: https://doi.org/10.1007/s13233-018-6100-6

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