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Fabrication of Radiopaque Poly(vinyl alcohol) Hydrogel Bilayers for Use as Embolization Coils

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Abstract

On purpose to replace the metallic embolization coils with a polymeric material, a series of poly(vinyl alcohol) (PVA) hydrogels was fabricated into the form of bilayers. A hydrogel layer was prepared by mixing aqueous PVA solution with tantalum particles for radiopacity, crosslinking the mixture with glutaraldehyde crosslinking agent, and casting to a film of desired thickness. The properties of the hydrogel films including expansion ratio and modulus were characterized. Two hydrogel films with different crosslinking density were attached to form a bilayer, which formed coils in the water with the diameter dictated by the difference in swelling ratio. The coils and bundles of coils with diameters between 1 to 6 mm were employed in the occlusion tests using glass models approximating brain aneurysms. The number and sequence of coil insertion to give high packing density were investigated. Packing density much higher than that of platinum coils was achieved with the polymer coils fabricated.

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References

  1. F. A. Serbinenko, J. Neurosurg., 41, 125 (1974).

    Article  CAS  PubMed  Google Scholar 

  2. R. T. Higashida, V. V. Halbach, S. L. Barnwell, C. Dowd, B. Dormandy, J. Bell, and G. B. Hieshima, Am. J. Neuroradiol., 11, 633 (1990).

    CAS  PubMed  Google Scholar 

  3. G. Guglielmi, F. Vinuela, J. Dion, and G. Duckwiler, J. Neurosurg., 75, 8 (1991).

    Article  CAS  PubMed  Google Scholar 

  4. G. Guglielmi, F. Vinuela, I. Sepetka, and V. Macellari, J. Neurosurg., 75, 1 (1991).

    Article  CAS  PubMed  Google Scholar 

  5. G. Guglielm, F. Vinuela, G. Duckwiler, J. Dion, P. Lylyk, A. Berenstein, C. Strother, V. Graves, V. Halbach, D. Nichols, N. Hopkins, R. Ferguson, and I. Sepetka, J. Neurosurg., 77, 515 (1992).

    Article  Google Scholar 

  6. G. Guglielmi, J. Stroke Cerebrovasc. Dis., 6, 246 (1997).

    Article  CAS  PubMed  Google Scholar 

  7. A. F. Zubillaga, G. Guglielmi, F. Vinuela, and G. R. Duckwiler, Am. J. Neuroradiol., 15, 815 (1994).

    Google Scholar 

  8. T. W. Malisch, G. Guglielmi, F. Vinuela, G. Duckwiler, P. Gobin, N. A. Martin, and J. G. Frazee, J. Neurosurg., 87, 176 (1997).

    Article  CAS  PubMed  Google Scholar 

  9. M. Sluzewski, T. Menovsky, W. J. Rooij, and D. Wijnalda, Am. J. Neuroradiol., 24, 257 (2003).

    PubMed  Google Scholar 

  10. G. Bavinzski, V. Talazoglu, M. Killer, B. Richiling, A. Gruber, C. E. Gross, and H. Plenk, J. Neurosurg., 91, 284 (1999).

    Article  CAS  PubMed  Google Scholar 

  11. D. F. Kallmes and N. H. Fujiwara, Am. J. Neuroradiol., 23, 1580 (2002).

    PubMed  Google Scholar 

  12. N. F. Fanning, Z. Berentei, P. R. Brennan, and J. Thornton, Neuroradiology, 49, 139 (2007).

    Article  PubMed  Google Scholar 

  13. H. J. Cloft, Am. J. Neuroradiol., 28, 152 (2007).

    CAS  PubMed  Google Scholar 

  14. P. M. White, S. C. Lewis, H. Nahser, R. J. Sellar, T. Goddard, and A. Gholkar, Am. J. Neuroradiol., 29, 217 (2008).

    Article  CAS  PubMed  Google Scholar 

  15. G. E. Klein, D. H. Szolar, R. Karaic, J. K. Stein, K. A. Hausegger, and H. H. Schreyer, Radiology, 201, 489 (1996).

    Article  CAS  PubMed  Google Scholar 

  16. R. C. Gaba, S. A. Ansari, S. S. Roy, F. A. Marden, M. A. G. Viana, and T. W. Malisch, Stroke, 37, 1443 (2006).

    Article  PubMed  Google Scholar 

  17. I. M. Germano, R. L. Davis, C. B. Wilson, and G. B. Hieshima, J. Neurosurg., 76, 607 (1992).

    Article  CAS  PubMed  Google Scholar 

  18. M. Guimaraes, D. Arrington, T. Macfall, R. Yamada, and C. Schonholz, Endovascular Today, April, 70 (2013).

    Google Scholar 

  19. Y. Yonekawa, Y. Kaku, and H. Iwata, Overview of Embolic Materials and Clinical Use of EVAL, A. Pasqualin and R. Da Pian, Eds., in New Trends in Management of Cerebro-Vascular Malformations, Springer, Vienna, 1994, pp 441–445.

  20. R. L. Vanninen and I. Manninen, Cardiovasc. Intervent. Radiol., 30, 196 (2007).

    Article  PubMed  Google Scholar 

  21. H. S. Cekirge, I. Saatci, M. H. Ozturk, B. Cil, A. Arat, M. Mawad, F. Ergungor, D. Belen, U. Er, S. Turk, M. Bavbek, Z. Sekerci, E. Beskonakli, O. E. Ozcan, and T. Ozgen, Neuroradiology, 48, 113 (2006).

    Article  PubMed  Google Scholar 

  22. J. E. Song, N. Tripathy, J. H. Shin, D. H. Lee, C. H. Park, and G. Khang, Macromol. Res., 24, 359 (2016).

    Article  CAS  Google Scholar 

  23. H. J. Cloft and D. F. Kallmes, Am. J. Neuroradiol., 25, 60 (2004).

    PubMed  Google Scholar 

  24. C. T. Reinhart and N. A. Pappas, J. Membr. Sci., 18, 227 (1984).

    Article  CAS  Google Scholar 

  25. K. J. Kim, S. B. Lee, and N. W. Han, Polym. J., 25, 1295 (1993).

    Article  CAS  Google Scholar 

  26. G. Guglielmi, Oper. Tech. Neurosurg., 3, 191 (2000).

    Article  Google Scholar 

  27. J. B. White, C. G. M. Ken, H. J. Cloft, and D. F. Kallmes, Am. J. Neuroradiol., 29, 1242 (2008).

    Article  CAS  PubMed  Google Scholar 

  28. R. Akhtar, M. J. Sherratt, J. K. Cruickshank, and B. Derby, Mater. Today, 14, 96 (2011).

    Article  CAS  Google Scholar 

  29. K. Baek, J. H. Jeong, A. Shkumatov, R. Bashir, and H. Kong, Adv. Mater., 25, 5568 (2013).

    Article  CAS  PubMed  Google Scholar 

  30. S. C. Jung, S. H. Choi, H. R. Cho, T. H. Lee, T. Y. Kim, W. Jeong, K. Rhee, J. Y. Jho, J. H. Kim, and M. H. Han, J. Vasc. Interv. Radiol., 26, 117 (2015).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. School of Chemical and Biological Engineering, Seoul National University, Seoul, 08826, Korea

    Tae Hoon Lee, Tae Yang Kim & Jae Young Jho

  2. Department of Mechanical Engineering, Myongji University, Yongin, Gyeonggi, 17046, Korea

    Kyehan Rhee

Authors
  1. Tae Hoon Lee
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  2. Tae Yang Kim
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  3. Kyehan Rhee
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  4. Jae Young Jho
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Correspondence to Jae Young Jho.

Additional information

Acknowledgments: This work was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea [A111101]. This work was also supported by Institute of Chemical Process at Seoul National University.

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Lee, T.H., Kim, T.Y., Rhee, K. et al. Fabrication of Radiopaque Poly(vinyl alcohol) Hydrogel Bilayers for Use as Embolization Coils. Macromol. Res. 26, 634–640 (2018). https://doi.org/10.1007/s13233-018-6083-3

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  • DOI: https://doi.org/10.1007/s13233-018-6083-3

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