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Macromolecular Research

, Volume 26, Issue 3, pp 270–277 | Cite as

pH-Sensitive Polypeptide Conjugated with Carborane Clusters and Cyanine for NIR Bioimaging and Multi-Therapies

  • Zheng Ruan
  • Pan Yuan
  • Titao Jing
  • Tao Xing
  • Lifeng Yan
Article

Abstract

A novel pH-sensitive carborane and cyanine dye conjugated polypeptide and its micelles has been designed and synthesized for potential near infrared fluorescence imaging-guided boron neutron capture therapy (BNCT). The amphiphilic polymer we synthesized with tertiary amine as functional group could self-assemble to micelle nanoparticles at neutral pH, and responsive to acidic solution for the disassembly of the micelles for drug release. The tertiary amine sensitive induced process was observed via dynamic light scattering (DLS) and transmission electron microscopy (TEM). The efficiency of cell killing ability is studied by MTT assays and fluorescence microscope measurement, indicating a new intelligent system for potential NIR imaging-guided therapy.

Keywords

pH-sensitive carborane tertiary amine imaging-guided boron neutron capture therapy 

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Copyright information

© The Polymer Society of Korea and Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, and Department of Chemical Physics, iChEMUniversity of Science and Technology of ChinaAnhuiP. R. China
  2. 2.Institute of System and EngineeringChinese Academy of Engineering PhysicsMianyangP. R. China

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