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Novel chemi-dynamic nanoparticles as a light-free photodynamic therapeutic system for cancer treatment

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Abstract

Photodynamic therapy (PDT) is a treatment modality, in which photosensitizers are activated by light of appropriate wavelength to convert molecular oxygen from triplet state (3O2) to singlet (1O2) that kills nearby cancer cells. However, the clinical application of PDT is limited to treat tumors on or just below the skin or the lining of internal organs because the light needed cannot pass through more than 1 cm of tissues. Here, we report chemi-dynamic nanoparticles (CDNP) as a light-free photodynamic therapeutic system based on peroxalate chemiluminescence. Photosensitizers are excited by the energy generated from hydrogen peroxide-mediated degradation of peroxalate to generate singlet oxygen to kill cancer cells. CDNP kill cancer cells without external light and hold potential as new anticancer drugs.

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Authors and Affiliations

  1. Department of BIN Convergence Technology, Chonbuk National University, Jeonju, Jeonbuk, 54896, Korea

    S. V. Berwin Singh, Jihye Kim, Hoyeon Park, Gilson Khang & Dongwon Lee

Authors
  1. S. V. Berwin Singh
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  2. Jihye Kim
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  3. Hoyeon Park
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  4. Gilson Khang
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  5. Dongwon Lee
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Corresponding author

Correspondence to Dongwon Lee.

Additional information

Acknowledgments: This work was supported by a grant of Korean Health Technology R&D Project (HI15C1619), Ministry of Health & Welfare and Basic Science Research Program (2016R1A2B4008489) through National Research Foundation funded by the Ministry of Education, Republic of Korea.

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Berwin Singh, S.V., Kim, J., Park, H. et al. Novel chemi-dynamic nanoparticles as a light-free photodynamic therapeutic system for cancer treatment. Macromol. Res. 25, 749–755 (2017). https://doi.org/10.1007/s13233-017-5078-9

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  • DOI: https://doi.org/10.1007/s13233-017-5078-9

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