Skip to main content
SpringerLink
Log in

Effect of magnesium hydroxide nanoparticles with rod and plate shape on mechanical and biological properties of poly(L-lactide) composites

  • Articles
  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

Two kinds of magnesium hydroxide (Mg(OH)2) rods (Mg-Rod, 150 and 350 nm in size) and plates (Mg-PL, 60 and 300 nm) were prepared, and blended with poly(L-lactide) (PLLA) to obtain PLLA/Mg(OH)2 composites to investigate the effect of the shape and size of Mg(OH)2 particles. The structure, morphology, pH change, thermal and mechanical properties, cytotoxicity, and inflammation of Mg(OH)2 control and PLLA/Mg(OH)2 composites were evaluated. PLLA/Mg-Rod150 (30%) composite showed a 50% higher tensile strength and a 45% improved modulus as compared with PLLA/Mg-PL300 30% composite. Although Mg-Rods displayed similar cell viability (above 80%) as compared to Mg-PLs, the expression levels of TNF-α from Mg-PL60 gradually increased with increasing concentrations from 1 to 300 μg. This indicates that Mg-PL60 had a potential cytotoxicity due to endocytosis. In addition, the byproduct of PLLA/Mg-Rods composite was more effectively neutralized than that of the PLLA/Mg-PLs composite, but cell viability and the expression levels of TNF-α were similar. Therefore, the use of our PLLA/Mg-Rod composite system would be a promising strategy to prevent the current fatal problems in biomedical applications including biodegradable implants such as stents.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. B. Jeong, Y. H. Bae, D. S. Lee, and S. W. Kim, Nature, 388, 860 (1997).

    Article  CAS  Google Scholar 

  2. L. E. Freed, G. Vunjak-Novakovic, R. J. Biron, D. B. Eagles, D. C. Lesnoy, S. K. Barlow, and R. Langer, Nat. Biotechnol., 12, 689 (1994).

    Article  CAS  Google Scholar 

  3. Y. K. Joung, B. N. Jang, J. H. Kang, and D. K. Han, Biomater. Biomed. Eng., 1, 13 (2014).

    Google Scholar 

  4. C. H. Park, Y. J. Hong, K. Park, and D. K. Han, Macromol. Res., 18, 526 (2010).

    Article  CAS  Google Scholar 

  5. G. Khang, J. M. Rhee, P. Shin, I. Y. Kim, B. Lee, S. J. Lee, Y. M. Lee, H. B. Lee, and I. Lee, Macromol. Res., 10, 158 (2002).

    Article  CAS  Google Scholar 

  6. M. Dunne, O. I. Corrigan, and Z. Ramtoola, Biomaterials, 21, 1659 (2000).

    Article  CAS  Google Scholar 

  7. K. H. Lam, J. M. Schakenraad, H. Groen, H. Esselbrugge, P. J. Dijkstra, J. Feijen, and P. Nieuwenhuis, J. Biomed. Mater. Res., 29, 929 (1995).

    Article  CAS  Google Scholar 

  8. W. J. van der Giessen, A. M. Lincoff, R. S. Schwartz, H. M. M. van Beusekom, P. W. Serruys, D. R. Holmes, S. G. Ellis, and E. J. Topol, Circulation, 94, 1690 (1996).

    Article  Google Scholar 

  9. T. Inoue, K. Croce, T. Morooka, M. Sakuma, K. Node, and D. I. Simon, J. Am. Coll. Cardiol., 4, 1057 (2011).

    Article  Google Scholar 

  10. J. M. Anderson, A. Rodriguez, and D. T. Chang, Semin Immunol., 20, 86 (2008).

    Article  CAS  Google Scholar 

  11. R. Kontio, P. Ruuttila, L. Lindroos, R. Suuronen, A. Salo, C. Lindqvist, I. Virtanen, and Y. T. Konttinen, Int. J. Oral Maxillofac. Surg., 34, 766 (2005).

    Article  CAS  Google Scholar 

  12. F. Vogt, A. Stein, G. Rettemeier, N. Krott, R. Hoffmann, J. vom Dahl, A.-K. Bosserhoff, W. Michaeli, P. Hanrath, C. Weber, and R. Blindt, Eur. Heart J., 25, 1330 (2004).

    Article  CAS  Google Scholar 

  13. O. Petillo, G. Peluso, L. Ambrosio, L. Nicolais, W. J. Kao, and J. M. Anderson, J. Biomed. Mater. Res., 28, 635 (1994).

    Article  CAS  Google Scholar 

  14. C. T. Hanks, J. C. Wataha, and Z. Sun, Dent. Mater., 12, 186 (1996).

    Article  CAS  Google Scholar 

  15. C. H. Kum, Y. J. Cho, Y. K. Joung, J. Y. Choi, K. D. Park, S. H. Seo, Y. S. Park, D. J. Ahn, and D. K. Han, J. Mater. Chem. B, 1, 2764 (2013).

    Article  CAS  Google Scholar 

  16. S.-Y. Fu, X.-Q. Feng, B. Lauke, and Y.-W. Mai, Compos. Part B: Eng., 39, 933 (2008).

    Article  Google Scholar 

  17. B. Y. Shin, G. S. Jo, K. S. Kang, T. J. Lee, B. S. Kim, S. I. Lee, and J. S. Song, Macromol. Res., 15, 291 (2007).

    Article  CAS  Google Scholar 

  18. D. Chen, L. Zhu, P. Liu, H. Zhang, K. Xu, and M. Chen, J. Porous Mater., 16, 13 (2009).

    Article  Google Scholar 

  19. C. Henrist, J.-P. Mathieu, C. Vogels, A. Rulmont, and R. Cloots, J. Cryst. Growth, 249, 321 (2003).

    Article  CAS  Google Scholar 

  20. Y. Li, M. Sui, Y. Ding, G. Zhang, J. Zhuang, and C. Wang, Adv. Mater., 12, 818 (2000).

    Article  CAS  Google Scholar 

  21. J. Lv, L. Qiu, and B. Qu, Nanotechnology, 15, 1576 (2004).

    Article  Google Scholar 

  22. M. Hayashi, H. Muramatsu, M. Sato, Y. Tomizuka, M. Inoue, and S. Yoshimoto, J. Craniomaxillofac. Surg., 41, 783 (2013).

    Article  Google Scholar 

  23. W. Jiang, B. Y. S. Kim, J. T. Rutka, and W. C. W. Chan, Nat. Nanotechnol., 3, 145 (2008).

    Article  CAS  Google Scholar 

  24. D. Chen, L. Zhu, P. Liu, H. Zhang, K. Xu, and M. Chen, J. Porous Mater., 16, 13 (2009).

    Article  Google Scholar 

  25. Y. Xiong, B. Wua, J. Zhu, X. Fan, P. Cai, J. Wen, and X. Liu, Hydrometallurgy, 142, 137 (2014).

    Article  CAS  Google Scholar 

  26. Y. Ding, G. Zhang, H. Wu, B. Hai, L. Wang, and Y. Qian, Chem. Mater., 13, 435 (2001).

    Article  CAS  Google Scholar 

  27. H. W. Lee, S. H. Seo, C. H. Kum, B. J. Park, Y. K. Joung, T. I. Son, and D. K. Han, Macromol. Res., 22, 210 (2014).

    Article  CAS  Google Scholar 

  28. Y. Li and X. S. Sun, Biomacromolecules, 11, 1847 (2010).

    Article  CAS  Google Scholar 

  29. I. C. McNeill and H. A. Leiper, Polym. Degrad. Stab., 11, 309 (1985).

    Article  CAS  Google Scholar 

  30. S. Xiong, S. George, H. Yu, R. Damoiseaux, B. France, K. Woei Ng, and J. S.-C. Loo, Arch. Toxicol., 87, 1075 (2013).

    Article  CAS  Google Scholar 

  31. M. V. D. Z. Park, A. M. Neigh, J. P. Vermeulen, L. J. J. de la Fonteyne, H. W. Verharen, J. J. Briedé, H. van Loveren, and W. H. de Jong, Biomaterials, 32, 9810 (2011).

    Article  CAS  Google Scholar 

  32. F. Zhao, Y. Zhao, Y. Liu, X. Chang, C. Chen, and Y. Zhao, Small, 1, 1322 (2011).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, 136-791, Korea

    Chang Hun Kum, Seong Ho Seo, Sung Nam Kang, Yoon Ki Joung & Dong Keun Han

  2. Department of Biomedical Engineering, Korea University of Science and Technology, Daejeon, 305-350, Korea

    Sung Nam Kang, Yoon Ki Joung & Dong Keun Han

  3. Department of Chemical and Biological Engineering, Korea University, Seoul, 136-701, Korea

    Chang Hun Kum & Dong June Ahn

  4. Department of Electronic Engineering and Institute of Gachon Fusion Technology, Gachon University, Gyeonggi, 461-701, Korea

    Bang Ju Park

Authors
  1. Chang Hun Kum
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Seong Ho Seo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sung Nam Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bang Ju Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dong June Ahn
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yoon Ki Joung
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Dong Keun Han
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yoon Ki Joung or Dong Keun Han.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kum, C.H., Seo, S.H., Kang, S.N. et al. Effect of magnesium hydroxide nanoparticles with rod and plate shape on mechanical and biological properties of poly(L-lactide) composites. Macromol. Res. 22, 1032–1041 (2014). https://doi.org/10.1007/s13233-014-2140-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13233-014-2140-8

Keywords

Search

Navigation