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Synthesis of thermo-sensitive polyelectrolyte complex nanoparticles from CS-g-PNIPAM and SA-g-PNIPAM for controlled drug release

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Abstract

In this paper, thermo-sensitive polyelectrolyte complex nanoparticles assembled from chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAM) and sodium alginate-graft-poly(N-isopropylacrylamide) (SA-g-PNIPAM) were prepared for entrapment and release of 5-fluorouracil (5-FU). The morphology and size of the nanoparticles were observed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The polyelectrolyte complex nanoparticles showed a narrow size distribution. The hydrogen bonding interactions between nanoparticles and 5-FU, which was determined by fourier-transformed infrared spectroscopy (FTIR), increased drug loading. Glutaraldehyde, as a cross-linking agent, reinforced the nanoparticle structure and decreased the burst drug release. When changing temperature, pH, or ionic strength, a sustained and controlled drug release was observed. The novel complex nanoparticles with environmentally sensitive properties are expected to be useful in the field of intelligent drug delivery system.

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Authors and Affiliations

  1. College of Chemistry and Materials Science, Ludong University, Yantai, 264025, P. R. China

    Minyi Qi, Guiying Li, Nana Yu, Yanfeng Meng & Xunyong Liu

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  1. Minyi Qi
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  2. Guiying Li
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  3. Nana Yu
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  4. Yanfeng Meng
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  5. Xunyong Liu
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Correspondence to Guiying Li.

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Qi, M., Li, G., Yu, N. et al. Synthesis of thermo-sensitive polyelectrolyte complex nanoparticles from CS-g-PNIPAM and SA-g-PNIPAM for controlled drug release. Macromol. Res. 22, 1004–1011 (2014). https://doi.org/10.1007/s13233-014-2134-6

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  • DOI: https://doi.org/10.1007/s13233-014-2134-6

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