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Prediction of Placenta Previa from Serial Reading of Serum Human Chorionic Gonadotropin Late in the First Half of Pregnancy

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Abstract

Background

Abnormally sited placenta is considered a major life-threatening condition for pregnant woman, and many debate about the way of early diagnosis and management to decrease the mortality and morbidity.

Aim of Study

To evaluate the role of beta-human chorionic gonadotrophin (B-HCG) level in the first half of pregnancy as a marker for prediction of placenta previa.

Study Design

This is a prospective study done in Al-Yarmouk Teaching Hospital from first of January 2020 till first of January 2021.

Material and Methods

A total of 57 patients have been recruited. For all participated women in this study were sampled between 14 and 18 weeks of gestational age for serum human chorionic gonadotropins measured in international units. Patients who developed placenta previa were diagnosed on the basis of development of vaginal bleeding either late in the second trimester or early in the second trimester. After developing vaginal bleeding, all patients were sent for routine ultrasound scan to confirm the presence of placenta previa.

Result

After recruiting a total of 57 women among which 14 patients were found to have placenta previa, ANOVA test shows a statistically significant difference between women with normal placenta and women with placenta previa P value < 0.001. Receiver operator characteristics curve was constructed to evaluate the optimum cutoff value for serum HCG between normal women and women with placenta previa sampled at 14–18 weeks of gestation. The optimum cutoff value is mean serum HCG > 105,380 IU in 14 weeks of gestation, and the sensitivity and specificity were calculated as 100% and 72.2%, respectively.

Conclusion

B-HCG level in first half of pregnancy can be used as a predictor marker for placenta previa.

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Acknowledgements

The authors would like to express their deepest appreciation to all those who provided them the possibility to complete this article.

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Authors and Affiliations

  1. Al-Mustansiriyah University, Baghdad, Iraq

    Shatha Sami Hussein (F.I.C.O.G, C.A.B.O.G Assistant Professor, Al-Mustansiriyah University), Manal Madany A. Qader (F.I.C.O.G, C.A.B.O.G Assistant Professor, Al-Mustansiriyah University) & Wisam Akram (F.I.C.O.G, Al-Mustansiriyah University)

Authors
  1. Shatha Sami Hussein
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  2. Manal Madany A. Qader
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  3. Wisam Akram
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Correspondence to Shatha Sami Hussein.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

This study was approved by the Institutional Review Board of the local hospital (Al-Yarmouk Teaching Hospital), in accordance with the Declaration of Helsinki 2013; in addition, participated women received appropriate management by the researchers.

Informed Consent

Written informed consent was obtained from each woman before participating in the study.

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Dr. Shatha Sami Hussein, Dr. Manal Madany A. Qader and Dr. Wisam Akram are working as an assistant professor, Department of Obstetrics and Gynecology Al-Mustansiriyah Medical College, Baghdad, Iraq.

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Hussein, S.S., Qader, M.M.A. & Akram, W. Prediction of Placenta Previa from Serial Reading of Serum Human Chorionic Gonadotropin Late in the First Half of Pregnancy. J Obstet Gynecol India 74, 27–30 (2024). https://doi.org/10.1007/s13224-023-01786-4

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  • DOI: https://doi.org/10.1007/s13224-023-01786-4

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