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Diclofenac Potassium Alone Versus Diclofenac Potassium with Hyoscine-N-butyl Bromide (HBB) in Reduction of Pain in Women Undergoing Office Hysteroscopy: A Double Blind Randomized, Placebo-Controlled Trial

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Abstract

Study Objective

To compare between oral diclofenac potassium alone versus a combination of it with hyoscine-N-butyl bromide (HBB) in reduction of pain in women undergoing office hysteroscopy.

Design

Randomized, double-blind controlled trial.

Setting

Kasralainy  hospital (a tertiary hospital).

Intervention

Sixty-Four patients undergoing office hysteroscopy were randomly divided into 2 groups (study group and placebo group) in the ratio of 1:1. Group 1 (study group = 32 participants) received two oral HBB tablets and one tablet of diclofenac potassium and group 2 (placebo group = 32 participants) received two oral placebo tablet similar in size, structure and color to buscopan in addition to the diclofenac tablet. The patient was given the drugs 30–60 min before the procedure.

Results

There was statistically significant difference between the two groups in the pain score immediately during entry (p value = 0.001) and after 30 min of the procedure (p value =  < 0.001). And there was a statistically significant difference as regards the side effects (gastric irritation) of the medications (p value = 0.04) between the women participating in the two groups.

Conclusion

The combination of diclofenac potassium and HBB helps a lot in decreasing the pain and discomfort during and after performing office hysteroscopy but with more gastric side effects.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt

    Ahmed S. S. A. Rashwan, Sarah Aboubakr Elkomaty, Omneya Mostafa Helal & Eman Aly Hussein

  2. Reproductive Health and Family Planning Department, National Research Centre, Giza, Egypt

    Mahmoud Alalfy

Authors
  1. Ahmed S. S. A. Rashwan
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  2. Mahmoud Alalfy
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  3. Sarah Aboubakr Elkomaty
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  4. Omneya Mostafa Helal
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  5. Eman Aly Hussein
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Correspondence to Mahmoud Alalfy.

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All authors declare that there are no any financial and personal relationships with other people or organizations that could inappropriately influence (bias) their work.

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Local Scientific and ethical Committee (an Institutional Review Board) approval was obtained before the start of the study.

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Rashwan, A.S.S.A., Alalfy, M., Elkomaty, S.A. et al. Diclofenac Potassium Alone Versus Diclofenac Potassium with Hyoscine-N-butyl Bromide (HBB) in Reduction of Pain in Women Undergoing Office Hysteroscopy: A Double Blind Randomized, Placebo-Controlled Trial. J Obstet Gynecol India 72 (Suppl 1), 340–345 (2022). https://doi.org/10.1007/s13224-022-01648-5

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  • DOI: https://doi.org/10.1007/s13224-022-01648-5

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