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Pretreatment Immune Status, Predicts Response to Definite Chemo Radiotherapy in Advanced Stages of Cervical Cancer Patients

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Abstract

Objective

To evaluate the prognostic role of pretreatment CD4 + , CD8 + T lymphocytes in predicting response to definite chemo radiotherapy in advanced cervical cancer. Design: A hospital-based prospective one-year follow-up study.

Method

This observational study was conducted on 74 patients with advanced cervical cancer. Pretreatment CD4 + and CD8 + levels in cervical cancer tissue and peripheral blood was noted and quantitatively assessed in patients with complete remission or persistent disease after one year of follow-up.

Results

There was a statistically significant association of tumour volume with the remission or persistence of disease. In peripheral blood, mean CD4 + score and CD4 + /CD8 + ratio were significantly higher while mean CD8 + score is significantly lower in patients with remission. Similar results were seen in tumour tissue as well. On Receiver Operating Curve analysis, the cut-off value of CD4 + , CD8 + and CD4 + /CD8 + ratio in predicting remission or persistent disease in peripheral blood was 20.09, 18.51 and 0.41 while in tumor tissue was 19.71, 20.99 and 0.20, respectively.

Conclusion

The patients with tumor volume < 100 cm 2 have much higher chances of remission. The patients with higher CD4 + and CD4 + / CD8 + ratio, both in peripheral blood as well as tumor tissue, have higher chances of remission. The cut-off value of CD4 + , CD8 + and CD4 + /CD8 + ratio in predicting remission or persistent disease in peripheral blood was 20.09, 18.51 and 0.41 while in tumor tissue was 19.71, 20.99 and 0.20, respectively.

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Authors and Affiliations

  1. Department of Obstetrics & Gynaecology, Mahatma Gandhi Medical College & Hospital, Jaipur, India

    Swati Garg & Usha Shekhawat

  2. Department of Community Medicine, Mahatma Gandhi Medical College & Hospital, Jaipur, India

    Rajaat Vohra

  3. Department of Physiology, Rajasthan University of Health & Sciences, Jaipur, India

    Reshu Gupta

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  1. Swati Garg
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  2. Usha Shekhawat
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Contributions

All authors contributed the study conception and design. Material preparation, data collection and analysis were performed by Dr. Swati Garg and Dr. Rajaat Vohra. The first draft of manuscript was written by Dr. Swati Garg and Dr. Reshu Gupta and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Swati Garg.

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Dr. Swati Garg, MS is a Professor & Unit Head, Department of Obstetrics & Gynaecology, Mahatma Gandhi Medical College & Hospital, Jaipur; Dr. Usha Shekhawat, MS is a Professor & Head, Department of Obstetrics & Gynaecology, Mahatma Gandhi Medical College & Hospital, Jaipur; Dr. Rajaat Vohra, MD is a Professor, Department of Community Medicine, Mahatma Gandhi Medical College & Hospital, Jaipur; Dr. Reshu Gupta, MD is a Professor, Department of Physiology, Rajasthan University of Health & Sciences, Jaipur.

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Garg, S., Shekhawat, U., Vohra, R. et al. Pretreatment Immune Status, Predicts Response to Definite Chemo Radiotherapy in Advanced Stages of Cervical Cancer Patients. J Obstet Gynecol India 72 (Suppl 1), 319–325 (2022). https://doi.org/10.1007/s13224-022-01624-z

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