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Uterine Sarcoma: Retrospective Study From A Single institute

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Abstract

Uterine sarcomas are heterogeneous group of tumours comprising 1% of gynaecological malignancies. There is lack of concences on optimal treatment of uterine sarcomas. This is because of lack of randomised controlled trials due to rarity of these tumours. Surgical management without spill remains the standard primary treatment. Most of the times uterine sarcomas are diagnosed postoperatively from histopathology report of either myomectomy or hysterectomy. This retrospective study analysed the clinico pathological characteristics, prognostic factors, treatment details and survival outcome of different types of uterine sarcomas.

Materials and methods

This is a retrospective analysis of 59 patients of uterine sarcomas. All patients underwent surgery. Adjuvant chemotherapy or radiation treatment were given according to histopathological report and FIGO stage. Patients were followed up every three months for first two years and then every six months. Disease free survival (DFS) and Overall survival (OS) were calculated.

Statistical analysis

The data were summarized using descriptive statistics as mean, percent and range. Survival probabilities were estimated using Kaplan–Meier method and the significance of difference between the survival curves were calculate using log-rank test.

Results

Uterine sarcomas are rare and aggressive tumours of uterus. Majority of these tumours present in early stage. Surgery remains the main treatment modality. Role of adjuvant radiation treatment remains controversial. Tumour stage is the most important prognostic factor.

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Authors and Affiliations

  1. Division of Gynaecologic Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India

    S. Suchetha, T. Vijayashanti (Seniour fellow) & P. Rema (Additional Professor)

  2. Division of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India

    J. Sivaranjith (Assistant Professor)

  3. Division of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India

    Aswin kumar (Additional Professor) & Francis. V. James (Professor)

  4. Division of Cancer Epidemiology& Biostatistics, Regional Cancer Centre, Thiruvananthapuram, Kerala, India

    K. M. Jagathnath Krishna (Additional Professor)

Authors
  1. S. Suchetha
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  2. T. Vijayashanti
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  3. P. Rema
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  4. J. Sivaranjith
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  5. Aswin kumar
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  6. K. M. Jagathnath Krishna
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  7. Francis. V. James
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Correspondence to S. Suchetha.

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Authors declare that they have no conflict of interest.

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This study has approval from the IRBðics committee.

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S. Suchetha: Additional professor. T. Vijayashanti: Seniour fellow. Rema. P Additional professor, J. Sivaranjith: Assistant Professor. Aswin kumar: Additional Professor. K. M. Jagathnath Krishna: Additional Professor. Francis. V. James: Professor.

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Suchetha, S., Vijayashanti, T., Rema, P. et al. Uterine Sarcoma: Retrospective Study From A Single institute. J Obstet Gynecol India 72 (Suppl 1), 306–312 (2022). https://doi.org/10.1007/s13224-021-01612-9

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  • DOI: https://doi.org/10.1007/s13224-021-01612-9

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