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Determinants of Survival in obstetric Sepsis: Retrospective Observational Study

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Abstract

Introduction

Sepsis is the dysregulated response of the body to the infection. Obstetric sepsis carries significantly greater morbidity and mortality as the condition is also augmented by the physiological adaptation of body during pregnancy. We conducted this study to determine the various epidemiological and clinical determinants of severity of sepsis which can help in prediction of survival in case of obstetric sepsis.

Materials and Methods

This retrospective study was conducted in a tertiary care center and all cases admitted with the diagnosis of obstetric sepsis as per the defined criteria between January 1, 2016 and December 31, 2020 were included in the study. Patients were evaluated for their clinical presentation, SOFA score, biochemical and microbiological parameters and the treatment given during their course of stay. Variables were compared among survivor and non-survivor group using appropriate statistical tests. Parameters which have significant association were further taken for binary logistic regression analysis.

Result

A total 46 patients of obstetric sepsis were admitted under defined criteria. Twelve out of 46 patients did not survive (26.09%). On statistical analysis, mean SOFA score (p = 0.005) as well as patients with SOFA score > 6 (p = 0.029), presence of multi organ failure (0.04) and septic shock (p = 0.012) were found to be significantly associated with mortality.

Conclusion

The study suggests that these determinants of survival should always be evaluated while catering to a patient of obstetric sepsis in order to guide the treatment, prognostication and improving outcome of the patients.

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Funding

No funding is received for this study.

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Authors and Affiliations

  1. Obstetrics and Gynaecology, AIIMS, Room No. 257, OPD Block (2-C), Patna, 801507, India

    Mukta Agarwal (Additional professor) & Shruti Singh (Post- graduate student)

  2. General Medicine, AIIMS, Room No. 149, OPD Block (1-C), Patna, 801507, India

    Divendu Bhushan (Assistant professor)

  3. Department of Pharmacology, AIIMS, Patna, 801507, India

    Shruti Singh (Assistant professor)

Authors
  1. Mukta Agarwal
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  2. Divendu Bhushan
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  3. Shruti Singh
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  4. Shruti Singh
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Corresponding author

Correspondence to Mukta Agarwal.

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Conflict of interest

Authors have no conflict of interest.

Ethical approval

The study was approved by Institute’s Ethics Committee via letter no. AIIMS/ Pat/IEC/2020/725 and individual patient’s consent was waived off as the study involves only secondary data analysis and there was no risk involved for the participants, and identity of the participants was not revealed at any point of time.

Human and animal rights

No patient is harmed in conducting this research and all rights of human participants keep protected, while conducting this research.

Informed consent

As this is a retrospective study involving secondary data analysis of available data of already treated patients, individual patient’s consent is waived off by the Institute’s Ethics Committee, and identity of any patient was not revealed at any point of time.

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Agarwal, M., Bhushan, D., Singh, S. et al. Determinants of Survival in obstetric Sepsis: Retrospective Observational Study. J Obstet Gynecol India 72 (Suppl 1), 159–165 (2022). https://doi.org/10.1007/s13224-021-01611-w

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  • DOI: https://doi.org/10.1007/s13224-021-01611-w

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