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Correlation of Clinical, Hormonal, Biochemical and Ultrasound Parameters Between Adult and Adolescent Polycystic Ovarian Syndrome

Adult and Adolescent PCOS

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Abstract

Purpose

To correlate the clinical, hormonal, biochemical and ultrasound parameters in adolescent patients with polycystic ovarian syndrome (PCOS) and to compare them with adult patients.

Methods

This was a prospective, correlational study. 50 adult (20–35 years) and 50 adolescent patients (15–19 years) who had features of PCOS (Rotterdam Criteria, 2003) were selected. The control group comprised of 50 women of same age in each group with normal parameters. Pelvic ultrasound was done in early follicular phase (3–5th day of menstrual cycle). Assessment of hormonal and biochemical parameters (LH/FSH ratio, free testosterone level, lipid profile and fasting glucose/insulin ratio) and grey-scale ultrasound was done.

Results

No significant difference was observed in menstrual pattern in adults and adolescents with PCOS. The mean values of serum LH/FSH ratio and free testosterone were significantly higher in both adult and adolescent PCOS patients as compared to their controls (p < 0.001). The mean value of serum insulin was significantly higher (p < 0.001) with positive correlation (adult: r = 0.655, p < 0.01; adolescent: r = 0.451, p < 0.01) of serum insulin with free testosterone. Hyperandrogenemia without hyperinsulinemia was found in 56% adolescent and 60% adult PCOS patients. 82% adolescent and 88% adult PCOS patients showed multiple follicles (> 5) on ultrasound. The ovarian morphology had positive correlation with serum LH and free testosterone. The mean ovarian volume was significantly higher in adult (10.48 ± 4.38 vs. 4.17 ± 0.91) and adolescent (11.08 ± 5.82 vs. 4.23 ± 0.89) PCOS patients, when compared with controls, respectively.

Conclusion

No statistically significant difference was noted in PCOS between adults and adolescents.

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Funding

This research did not receive any specific grant from funding agencies.

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Authors and Affiliations

  1. Department of Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India

    Shivi Jain M.D. Radiodiagnosis (Associate Professor) & R. C. Shukla M.D. Radiodiagnosis (Professor)

  2. Department of Obstetrics and Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India

    Madhu Jain M.D. Obstetrics & Gynaecology (Professor)

Authors
  1. Shivi Jain M.D. Radiodiagnosis
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  3. R. C. Shukla M.D. Radiodiagnosis
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Correspondence to Madhu Jain M.D. Obstetrics & Gynaecology.

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The authors declare that they have no conflict of interest.

Human and Animal Rights

This article does not contain any studies with animal subjects.

Ethical Approval

The study was performed after approval of the institutional ethical committee of the Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional ethical committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

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Informed consent was obtained from all the individual participants included in the study.

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Madhu Jain : M.D. Obstetrics & Gynaecology; Professor, Department of Obstetrics & Gynaecology, Institute of Medical Sciences, Banaras Hindu University

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Jain, S., Jain, M. & Shukla, R.C. Correlation of Clinical, Hormonal, Biochemical and Ultrasound Parameters Between Adult and Adolescent Polycystic Ovarian Syndrome. J Obstet Gynecol India 72 (Suppl 1), 274–280 (2022). https://doi.org/10.1007/s13224-021-01557-z

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