Skip to main content

A Rare Case of Gestational Choriocarcinoma with Lung and Vaginal Metastases with Obstructive Jaundice

Abstract

Choriocarcinoma is a rare highly malignant neoplasm which may present with early metastases as it has a propensity of rapid haematogenous spread. However the neoplasm is chemosensitive and has a good prognosis even in advanced stages. We are presenting a case of a 26 years old female with early pregnancy presented with lung and vaginal metastases with obstructive jaundice. [International Federation of Gynaecology and Obstetrics (FIGO) stage III; World Health Organization score, 14]. Serum beta-hCG was 3,61,131 mIU/ml. Radiological evaluation suggested marked lung metastases with vaginal metastases. Patient was started on single agent chemotherapy doxorubicin in view of deranged liver function test. Patient was given 5 cycles of doxorubicin with liver function test and beta hcg monitoring. After liver function test normalized, patient was shifted to EMACO regimen for 6 cycles of treatment dose and 2 cycles of maintenance dose.

This is a preview of subscription content, access via your institution.

Fig. 1

References

  1. May T, Goldstein DP, Berkowitz RS. Current chemotherapeutic management of patients with gestational trophoblastic neoplasia. Chemother Res Pract. 2011:8062562011.PubMed/NCBI

  2. Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010;203(6):531–9.

    Article  Google Scholar 

  3. Oranratanaphan S, Lertkhachonsuk R. Treatment of extremely high risk and resistant gestational trophoblastic neoplasia patients in King Chulalongkorn Memorial Hospital. Asian Pac J Cancer Prev. 2014;15:925–8.

    Article  Google Scholar 

  4. Lawrie TA, Alazzam M, Tidy J, et al. First line chemotherapy in low risk GTN. Cochrane Database Syst Rev 2016;CD007102.

Download references

Acknowledgements

We acknowledge Dr. Puneet Pareek, Additional Professor, Department of Radiation Oncology and his team for helping in the management of this patient.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shivani Gupta.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Dr.Shivani Gupta, Senior resident, Department of Obstetrics and Gynecology, AIIMS Jodhpur. Dr.Manisha Jhirwal, Assistant Professor, Department of Obstetrics and Gynecology, AIIMS Jodhpur. Dr.Charu Sharma, Associate Professor, Department of Obstetrics and Gynecology, AIIMS Jodhpur. Dr.Shashank Shekhar, Professor, Department of Obstetrics and Gynecology, AIIMS Jodhpur.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Gupta, S., Jhirwal, M., Sharma, C. et al. A Rare Case of Gestational Choriocarcinoma with Lung and Vaginal Metastases with Obstructive Jaundice. J Obstet Gynecol India 72, 262–264 (2022). https://doi.org/10.1007/s13224-021-01490-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13224-021-01490-1

Keywords

  • Doxorubicin
  • EMACO
  • Beta hCG
  • Molar pregnancy
  • Chemotherapy