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Role of Cervical Phosphorylated Insulin-Like Growth Factor-Binding Protein 1 (phIGFBP1) for Prediction of Successful Induction Among Primigravida with Prolonged Pregnancy

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Abstract

Purpose of the Study

To estimate and to compare the levels of cervical phIGFBP-1 among primigravida with prolonged pregnancy, with and without successful induction of labor (IOL).

Methods

A diagnostic study (cross-sectional study design) was conducted in our institution from November 2016 to April 2018 on 84 primigravida at ≥ 41 weeks with uncomplicated singleton pregnancy. The results were analyzed using SPSS software and receiver operating characteristics curves to determine the best cutoff using Youden Index. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive (+ LR) and negative likelihood ratio (− LR) were calculated. P value < 0.05 was considered significant. Logistic regression analysis was used to determine the predictive ability of the three markers for successful IOL.

Results

The cutoff level of phIGFBP-1, Bishop score (BS) and transvaginal cervical length (TVL) were 7.8 µg/l, 3 and 3.5 cm, respectively. The sensitivity, specificity, PPV, NPV, + LR and − LR of phIGFBP-1 (> 7.8 µg/l) were 0.87, 0.87, 0.89, 0.85, 6.76 and 0.15, respectively. Using logistic regression analysis, phIGFBP-1 was found to be the best predictor of successful IOL (OR 44.200; 95% CI 12.378–157.831, p < 0.001).

Conclusion

phIGFBP-1 is a strong independent predictor successful IOL as compared to TVL and BS in primigravida with prolonged pregnancy.

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Acknowledgements

This study was conducted at UCMS & GTB hospital, Delhi, India.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, UCMS & GTB Hospital, Delhi, India

    Aayushi Rathore, Richa Sharma, Amita Suneja & Kiran Guleria

  2. Department of Biochemistry, UCMS & GTB Hospital, Delhi, India

    Rajarshi Kar

  3. Department of Radio-Diagnosis, UCMS & GTB Hospital, Delhi, India

    Anupama Tandon

Authors
  1. Aayushi Rathore
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  2. Richa Sharma
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  5. Amita Suneja
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  6. Kiran Guleria
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Correspondence to Aayushi Rathore.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

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Aayushi Rathore is a Resident at Department of Obstetrics and Gynecology, UCMS & GTB Hospital, Delhi, India; Richa Sharma is a Assistant Professor at Department of Obstetrics and Gynecology, UCMS & GTB Hospital, Delhi, India; Rajarshi Kar is a Assistant Professor at Department of Biochemistry, UCMS & GTB Hospital, Delhi, India; Anupama Tandon is a Associate Professor at Department of Radio-Diagnosis, UCMS & GTB Hospital, Delhi, India; Amita Suneja is a Director Professor and Head at Department of Obstetrics and Gynecology, UCMS & GTB Hospital, Delhi, India; Kiran Guleria is a Director Professor at Department of Obstetrics and Gynecology, UCMS & GTB Hospital, Delhi, India.

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Rathore, A., Sharma, R., Kar, R. et al. Role of Cervical Phosphorylated Insulin-Like Growth Factor-Binding Protein 1 (phIGFBP1) for Prediction of Successful Induction Among Primigravida with Prolonged Pregnancy. J Obstet Gynecol India 71, 38–44 (2021). https://doi.org/10.1007/s13224-020-01372-y

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  • DOI: https://doi.org/10.1007/s13224-020-01372-y

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