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Impact of Vitamin D Supplementation on Semen Quality in Vitamin D-Deficient Infertile Males with Oligoasthenozoospermia

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Abstract

Introduction

Male factor contributes to almost 50% cases of infertility. There is evidence of the effect of serum vitamin D on male fertility by helping in spermatozoa maturation and initiating acrosomal reaction. In India, vitamin D deficiency has been documented to be in the range of 50–90% among all the age groups.

Objective

To study the levels of vitamin D and the impact of vitamin D supplementation in vitamin D-insufficient/deficient infertile males with oligoasthenozoospermia.

Material and methods

This study is a longitudinal observation study. Infertile men with either oligozoospermia or asthenozoospermia with vitamin D levels < 30 ng/ml were enrolled. Vitamin D and calcium supplementation was given, and semen and hormone parameters were assessed at the end of 3 and 6 months.

Result

There is significant improvement in the mean sperm concentration and progressive sperm motility in infertile males with oligoasthenozoospermia after 6 months of vitamin D supplementation (p value < 0.001). The overall clinical pregnancy rate in the study was 8.33% after vitamin D supplementation (p value 0.24).

Conclusion

Vitamin D supplementation plays a crucial role in regulating male fertility.

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References

  1. Calverton, Maryland, USA: ORC Macro and the World Health Organization; 2004. World Health Organization. Infecundity, Infertility, and Childlessness in Developing Countries. DHS Comparative Reports No 9.

  2. Anthony H. Male subfertility. BMJ. 2003;327(7416):669–72.

    Article  Google Scholar 

  3. Corbett ST, Hill O, Nangia AK. Vitamin D receptor found in human sperm. Urology. 2006;68:1345–9.

    Article  Google Scholar 

  4. Jensen BM, Jorgensen A, Nielsen JE, et al. Expression of the vitamin D metabolizing enzyme CYP21A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality. Int J Androl. 2012;35(4):499–510.

    Article  Google Scholar 

  5. Harinarayan CV, Joshi SR. Vitamin D status in India—its implications and remedial measures. J Assoc Physicians India. 2009;57:40–8.

    CAS  PubMed  Google Scholar 

  6. Ramlau-Hansen CH, Moeller UK, Bonde JP, et al. Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertil Steril. 2011;95:1000–4.

    Article  CAS  Google Scholar 

  7. Jensen BM, Bjerrum PJ, Jessen TE, et al. vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod. 2011;26:1307–17.

    Article  Google Scholar 

  8. Özdemir E, Tokmak A, Erkılınç S, et al. Association between vitamin D levels and semen parameters in infertile males. J Clin Anal Med. 2015;6:765–9.

    Google Scholar 

  9. Jensen BM, GernerLawaetz J, Andersson A, et al. Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men. Hum Reprod. 2016;31(8):1875–85.

    Article  CAS  Google Scholar 

  10. Hammoud A, Meikle A, Matthew CP, et al. Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl. 2012;14(6):855–9.

    Article  CAS  Google Scholar 

  11. Deng XL, Li YM, Yang XY, et al. Efficacy and safety of vitamin D in the treatment of idiopathic oligoasthenozoospermia. Zhonghua Nan KeXue. 2014;20(12):1082–5.

    Google Scholar 

  12. Jensen BM, Lawaetz JG, Petersen JH, et al. Effects of vitamin D supplementation on semen quality, reproductive hormones, and live birth rate: a randomized clinical trial. J Clin Endocrinol Metab. 2018;103(3):870–81.

    Article  Google Scholar 

  13. Lerchbaum E, Pilz S, Trummer C, et al. Serum vitamin D levels and hypogonadism in men. Int J Andrology. 2014;2:748–54.

    Article  CAS  Google Scholar 

  14. Lee DM, Tajar A, Pye SR, et al. Association of hypogonadism with vitamin D status: the European Male Ageing Study. Eur J Endocrinol. 2012;166:77–8.

    Article  CAS  Google Scholar 

  15. Pilz S, Frisch S, Koertke H, et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res. 2011;43(3):223–5.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, ESIC-PGIMSR Basaidarapur, Delhi, 110015, India

    Leena Wadhwa, Srishti Priyadarshini, Ashish Fauzdar & Sanjana N. Wadhwa

  2. ESIC-PGIMSR Basaidarapur, Delhi, India

    Sarika Arora

Authors
  1. Leena Wadhwa
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  2. Srishti Priyadarshini
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  3. Ashish Fauzdar
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  4. Sanjana N. Wadhwa
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  5. Sarika Arora
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Corresponding author

Correspondence to Srishti Priyadarshini.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Standard

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5).

Human and Animal Studies

This article does not contain any study with animal subjects.

Informed Consent

Informed consent was obtained from all patients for being included in the study.

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Dr. Leena Wadhwa, MD, DNB, MNAMS, FICOG is a Professor in Obstetrics and Gynaecology, ESIC-PGIMSR Basaidarapur, Delhi. Dr. Srishti Priyadarshini, MBBS is a Post graduate student in Obstetrics and Gyanecology, ESIC-PGIMSR Basaidarapur, Delhi. Dr. Ashish Fauzdar, Ph.D. is a Embryologist in Obstetrics and Gyanecology, ESIC-PGIMSR Basaidarapur, Delhi. Dr. Sanjana N. Wadhwa MBBS, DNB is a Assistant Professor in Obstetrics and Gyanecology, ESIC-PGIMSR Basaidarapur, Delhi. Dr. Sarika Arora, MBBS, MD Biochemistry is a Professor in ESIC-PGIMSR Basaidarapur, Delhi.

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Wadhwa, L., Priyadarshini, S., Fauzdar, A. et al. Impact of Vitamin D Supplementation on Semen Quality in Vitamin D-Deficient Infertile Males with Oligoasthenozoospermia. J Obstet Gynecol India 70, 44–49 (2020). https://doi.org/10.1007/s13224-019-01251-1

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  • DOI: https://doi.org/10.1007/s13224-019-01251-1

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