Advances in Diagnosis of Endometrial Hyperplasia
Recent classification of endometrial hyperplasia (EM) has improved our understanding on endometrioid adenocarcinomas (ECs). There was a previous notion that an unopposed oestrogenic stimulation leads to hyperplastic proliferation and cytological atypia leading to development of EC. The recent concepts point towards Endometrial Intra Epithelial Neoplasia as mutationally activated and monoclonally imprinted condition (Sanderson et al. in Hum Reprod Update 23(2):232–254, 2017. https://doi.org/10.1093/humupd/dmw042). Several diagnostic biomarkers are described which can prognosticate development to EC. A ‘Panel approach’ to these biomarkers will help to prognosticate the disease progression (2016).
KeywordsEndometrial intra epithelial neoplasia (EIN) Endometrial hyperplasia Biomarkers
Compliance with Ethical Standards
Conflict of interest
The author declares that she has no conflict of interest.
- 5.Gallos ID, Alazzam M, Clark T, et al. RCOG green-top guideline: management of endometrial hyperplasia. 2016. https://www.rcog.org.uk/globalassets/documents/guidelines/green-top-guidelines/gtg_67_endometrial_hyperplasia.pdf.