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Amniotic Fluid Stem Cells: A New Era in Regenerative Medicine

  • Mala Srivastava
  • Neha Ahlawat
  • Ankita Srivastava
Invited Mini Review

Abstract

Regenerative medicine has become an emerging field which focuses on repair, replacement or regeneration of cells, tissues and the entire organs. The regeneration may occur in patient’s own body by using their system as a bioreactor, e.g., cell therapy that involves transplantation of stem cells capable of proliferating, differentiating and replacing damaged host cells. As the field of regenerative medicine advances, and sources of stem cells has been intensified. Though embryonic and adult tissues can be used for isolation of pluripotent stem cells, the amniotic fluid (AF) has been proposed as an alternative source of stem cells for tissue regeneration. AF cells could be banked and used for either allogeneic or autologous transplantation.

Keywords

Stem cell Banking Regenerative medicine Amniotic fluid Transplantation Allogenic Autologous 

References

  1. 1.
    Elliott MJ, De CP, Speggiorin S, et al. Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year followup study. Lancet. 2012;380(9846):994–1000.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Baraniak PR, McDevitt TC. Stem cell paracrine actions and tissue regeneration. Regen Med. 2010;1:121–43.CrossRefGoogle Scholar
  3. 3.
    Zani A, Cananzi M, Fascetti-Leon F, et al. Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism. Gut. 2014;2:300–9.CrossRefGoogle Scholar
  4. 4.
    Calvin SE, Oyen ML. Microstructure and mechanics of the chorioamnion membrane with an emphasis on fracture properties. Ann N Y Acad Sci. 2007;1101:166–85.CrossRefPubMedGoogle Scholar
  5. 5.
    Lotgering FK, Wallenburg HC. Mechanisms of production and clearance of amniotic fluid. Semin Perinatol. 1986;10(2):94e102.Google Scholar
  6. 6.
    Cananzi M, Atala A, De CP. Stem cells derived from amniotic fluid: new potentials in regenerative medicine. Reprod Biomed Online. 2009;18(Suppl. 1):17–27.CrossRefPubMedGoogle Scholar
  7. 7.
    Gosden C, Brock DJ. Combined use of alphafetoprotein and amniotic fluid cell morphology in early prenatal diagnosis of fetal abnormalities. J Med Genet. 1978;15(4):262–70.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Hoehn H, Bryant EM, Karp LE, et al. Cultivated cells from diagnostic amniocentesis in second trimester pregnancies. II. Cytogenetic parameters as functions of clonal type and preparative technique. Clin Genet. 1975;7(1):29–36.CrossRefPubMedGoogle Scholar
  9. 9.
    Streubel B, Martucci-Ivessa G, Fleck T, et al. In vitro transformation of amniotic cells to muscle cells—background and outlook. Wien Med Wochenschr. 1996;146(9–10):216–7.PubMedGoogle Scholar
  10. 10.
    De CP, Bartsch G Jr, Siddiqui MM, et al. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007;25(1):100–6.CrossRefGoogle Scholar
  11. 11.
    Parolini O, Soncini M, Evangelista M, et al. Amniotic membrane and amniotic fluid-derived cells: potential tools for regenerative medicine? Regen Med. 2009;4(2):275–91.CrossRefPubMedGoogle Scholar
  12. 12.
    Bollini S, Cheung KK, Riegler J, et al. Amniotic fluid stem cells are cardioprotective following acute myocardial infarction. Stem Cells Dev. 2011;20(11):1985–94.CrossRefPubMedGoogle Scholar
  13. 13.
    Angelini A, Castellani C, Ravara B, et al. Stem-cell therapy in an experimental model of pulmonary hypertension and right heart failure: role of paracrine and neurohormonal milieu in the remodeling process. J Heart Lung Transplant. 2011;30(11):1281–93.CrossRefPubMedGoogle Scholar
  14. 14.
    Loukogeorgakis SP, Flake AW. In utero stem cell and gene therapy: current status and future perspectives. Eur J Pediatr Surg. 2014;24(3):237–45.CrossRefPubMedGoogle Scholar
  15. 15.
    Sun H, Feng K, Hu J, et al. Osteogenic differentiation of human amniotic fluid-derived stem cells induced by bone morphogenetic protein-7 and enhanced by nanofibrous scaffolds. Biomaterials. 2010;31(6):1133–9.CrossRefPubMedGoogle Scholar
  16. 16.
    Piccoli M, Franzin C, Bertin E, et al. Amniotic fluid stem cells restore the muscle cell niche in a HSA-Cre, Smn(F7/F7) mouse model. Stem Cells. 2012;30(8):1675–84.CrossRefPubMedGoogle Scholar
  17. 17.
    Pederiva F, Ghionzoli M, Pierro A, et al. Amniotic fluid stem cells rescue both in vitro and in vivo growth, innervation, and motility in nitrofen-exposed hypoplastic rat lungs through paracrine effects. Cell Transplant. 2013;22(9):1683–94.CrossRefPubMedGoogle Scholar
  18. 18.
    Metcalfe AD, Ferguson MW. Bioengineering skin using mechanisms of regeneration and repair. Biomaterials. 2007;28:5100–13.CrossRefPubMedGoogle Scholar
  19. 19.
    Alsbjorn B. In search of an ideal skin substitute. Scand J Plast Reconstr Surg. 1984;18:127–33.CrossRefPubMedGoogle Scholar
  20. 20.
    Odorico JS, Kaufman DS, Thomson JA. Multilineage differentiation from human embryonic stem cell lines. Stem Cells. 2001;19:193–204.CrossRefPubMedGoogle Scholar
  21. 21.
    Tsai MS, Lee JL, Chang YJ, et al. Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol. Hum Reprod. 2004;19:1450–6.CrossRefPubMedGoogle Scholar
  22. 22.
    Perin L, Giuliani S, Jin D, et al. Renal differentiation of amniotic fluid stem cells. Cell Prolif. 2007;40(6):936–48.CrossRefPubMedGoogle Scholar
  23. 23.
    Pan HC, Yang DY, Chiu YT, et al. Enhanced regeneration in injured sciatic nerve by human amniotic mesenchymal stem cell. J Clin Neurosci. 2006;13(5):570–5.CrossRefPubMedGoogle Scholar
  24. 24.
    Pan HC, Cheng FC, Chen CJ, et al. Post-injury regeneration in rat sciatic nerve facilitated by neurotrophic factors secreted by amniotic fluid mesenchymal stem cells. J Clin Neurosci. 2007;14(11):1089–98.CrossRefPubMedGoogle Scholar
  25. 25.
    Ekblad A, Qian H, Westgren M, et al. Amniotic fluid—a source for clinical therapeutics in the newborn? Stem Cells Dev. 2015;24(12):1405–14.CrossRefPubMedGoogle Scholar

Copyright information

© Federation of Obstetric & Gynecological Societies of India 2017

Authors and Affiliations

  • Mala Srivastava
    • 1
  • Neha Ahlawat
    • 1
  • Ankita Srivastava
    • 2
  1. 1.Institute of Obstetrics and GynaecologySir Ganga Ram HospitalNew DelhiIndia
  2. 2.Department of Obstetrics and GynaecologyLok Nayak Jay Prakash HospitalNew DelhiIndia

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