Analyses of Nutrients and Body Mass Index as Risk Factor for Preeclampsia
Little is known about the pathogenesis of preeclampsia. Many factors are identified as risk factors for preeclampsia including nutrients and obesity. The aim of this study was to assess whether nutrients and body mass index (BMI) are risk factors for preeclampsia.
This was a case–control study at the Department of Obstetric and Gynecology in Dr. M. Djamil Hospital, Padang, Indonesia. A total of 140 patients were enrolled in this study with 70 cases and 70 controls. All subjects completed an interview for their nutritional status and prepregnancy BMI after delivery. The nutritional status was assessed by Food Frequency Questionnaire and then analyzed by Nutrisurvey Program. The independent samples t test was used for nutritional status, and Chi-square test was used for BMI. For nutrients, logistic regression procedures were employed to calculate potential risk factors associated with preeclampsia.
Prevalence of abnormal BMI was more common in the preeclampsia group compared with those without preeclampsia 19 (27.1%) versus 12 (17.1%) but not found as a significant risk factor in this study (p = 0.222). Deficiency of vitamin E (OR 1.76, 95% CI 10.2 ± 30.5), zinc (OR 99.4, 95% CI 1.37 ± 7219), fat (OR 59.1, 95% CI 3.14 ± 500), calcium (OR 109, 95% CI 0.29 ± 40,041), vitamin C (OR 19.5, 95% CI 2.52 ± 151) were associated with increased risk of preeclampsia. Excess of carbohydrate was associated with increased risk of preeclampsia (OR 52.9, 95% CI 0.801 ± 3495).
Deficiency of vitamin E, zinc, fat, calcium, and vitamin C, and excess of calories and carbohydrate were associated with increased risk of preeclampsia.
KeywordsBody mass index Nutrition Preeclampsia Risk factor
We thank staffs at RSUP Dr. M. Djamil Padang who facilitated us in data collection and for all the subjects that have agreed to participate in this study.
Compliance with Ethical Standards
Conflict of interest
Yusrawati, Nicko Pisceski Kusika Saputra, Nur Indrawati Lipoeto, Rizanda Machmud declare that they have no conflict of interest.
Human and Animal Right Statements
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. The study was approved by the Research Ethics of the Dr. M. Djamil Hospital (Project Number PE.10.2014).
Informed consent was obtained from all patients for being included in this study.
- 9.Lamers Y, Coats B, Rolat M, et al. Moderate vitamin B6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women. J Nutr. 2011;141(5):835–42. doi: 10.3945/jn.110.134197.CrossRefPubMedPubMedCentralGoogle Scholar