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Carboprost Versus Oxytocin for Active Management of Third Stage of Labor: A Prospective Randomized Control Study

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Abstract

Background and Objectives

Postpartum hemorrhage is the single largest and leading cause of maternal morbidity and mortality not only in developing countries but also in developed countries. The present study is an attempt to evaluate the scope of using prophylactic intramuscular carboprost tromethamine 125 μg in comparison with intramuscular oxytocin 10 units for the active management of third stage of labor.

Materials and Methods

Two hundred pregnant women at term with spontaneous onset of labor were included in the study and were randomly divided into 2 groups of 100 women each. Group A and group B were given injection oxytocin 10 units and injection carboprost tromethamine 125 μg intramuscularly, respectively, at the time of delivery of anterior shoulder. The main outcome measures with respect to third stage of labor were: duration, blood loss by volume, difference in hemoglobin, need for additional oxytocics and side effects.

Results

Subjects who received carboprost tromethamine 125 μg showed a significant reduction in duration of third stage of labor (p < 0.05) and blood loss (p < 0.01) when compared to the subjects who received oxytocin 10 units. Likelihood of occurrence of postpartum hemorrhage was reduced without significant side effects except for diarrhea. Additional need for other uterotonics after carboprost was significantly less compared to oxytocin.

Conclusion

Intramuscular carboprost 125 μg is a better cost-effective alternative as compared to 10 units intramuscular oxytocin in active management of third stage of labor.

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Authors and Affiliations

  1. Department of OBGYN, SDM College of Medical Sciences and Hospital, Sattur, Dharwad, Karnataka, 580009, India

    K. S. Sunil Kumar & Sundar Shyam

  2. Department of OBGYN, Ashirwada Hospital, MIG 226, Navanagar, Hubli, Karnataka, India

    Pavitra Batakurki

Authors
  1. K. S. Sunil Kumar
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  2. Sundar Shyam
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  3. Pavitra Batakurki
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Corresponding author

Correspondence to K. S. Sunil Kumar.

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Conflict of interest

All authors of the study declare that there is no conflict of interest of any type.

Ethical Statement

Permission was obtained from the ethical committee of the institution.

Additional information

Dr. K. S. Sunil Kumar is Professor and Unit Head, and Dr. Sundar Shyam is Assistant Professor in Department of OBGYN at SDM College of Medical Sciences and Hospital; Dr. Pavitra Batakurki is Consultant in Department of OBGYN at Ashirwada Hospital.

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Sunil Kumar, K.S., Shyam, S. & Batakurki, P. Carboprost Versus Oxytocin for Active Management of Third Stage of Labor: A Prospective Randomized Control Study. J Obstet Gynecol India 66 (Suppl 1), 229–234 (2016). https://doi.org/10.1007/s13224-016-0842-x

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  • DOI: https://doi.org/10.1007/s13224-016-0842-x

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