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A Retrospective Case–Control Study Evaluating the Role of Mifepristone for Induction of Labor in Women with Previous Cesarean Section

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Abstract

Objective

To investigate the role of “mifepristone” for induction of labor (IOL) in pregnant women with prior cesarean section (CS).

Methods

In this retrospective study, all pregnant women with prior CS who received oral mifepristone (400 mg) for IOL (as per clear obstetric indications) [group 1] were compared with pregnant women with prior CS who had spontaneous onset of labor (SOL) [group 2], with respect to incidence of vaginal delivery, CS, duration of labor, and various maternal and fetal outcomes.

Results

During the study period, 72 women received mifepristone (group 1) for IOL and 346 had SOL (group 2). In group 1 after mifepristone administration, 40 (55.6 %) women had labor onset, and 24 (33.3 %) women had cervical ripening (Bishop Score ≥ 8) within 48 h. There were no statistically significant differences with respect to duration of labor (p value: 0.681), mode of delivery (i.e., normal delivery or CS—p value: 0.076 or 0.120, respectively), or maternal (blood loss or scar dehiscence/rupture uterus), or fetal outcomes (NICU admission) compared to women with previous CS with SOL (group 2). However, the need of oxytocin (p value 0.020) and dose of oxytocin requirement (p value 0.008) were more statistically significant in group 1.

Conclusion

Mifepristone may be considered as an agent for IOL in women with prior CS.

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Authors and Affiliations

  1. Department of OBG, Dr. Rajendra Prasad Government Medical College (Dr RPGMC) Kangra at Tanda (HP), Set No. 112, Vivekanand Hostel, Dr RPGMC, Kangra, HP, 176001, India

    Chanderdeep Sharma, Anjali Soni, Pawan K. Soni, Suresh Verma, Ashok Verma & Amit Gupta

Authors
  1. Chanderdeep Sharma
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  2. Anjali Soni
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  3. Pawan K. Soni
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  4. Suresh Verma
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  5. Ashok Verma
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  6. Amit Gupta
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Correspondence to Chanderdeep Sharma.

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Conflict of Interest

There is no conflict of interest with any individual or organization.

Ethical Statement

Compliance with ethical requirements and Conflict of interest Ethical clearance has been taken from ethical committee of Dr. RPGMC Kangra at Tanda (HFW-H-DRPGMC/Ethics/2014) keeping in view the ICMR guidelines (1994) and Helinski declaration (modified 2000). Written informed consent was taken from all the women. Identity of every women is kept as secret. All the women were adequately informed of the aims, methods, and any discomfort it may entail to her and the remedies thereof. Every precaution was taken to respect the privacy of the patient, the confidentiality of the patient’s information, and to minimize the impact of the study on her physical and mental integrity and her personality. The patient was given the right to abstain from the study or to withdraw consent to participate at any time of study without reappraisal.

Additional information

Dr. Chanderdeep Sharma is an Assistant Professor, Dr. Anjali Soni is an Associate Professor, Dr. Pawan K. Soni is an Assistant Professor (Radio-diagnosis), Dr. Suresh Verma is a Professor and the Head, Dr. Ashok Verma is an Associate Professor, Dr. Amit Gupta is an Associate Professor at the Department of OBG, Dr. Rajendra Prasad Government Medical College (Dr. RPGMC) Kangra at Tanda (HP), Kangra, HP, India.

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Sharma, C., Soni, A., Soni, P.K. et al. A Retrospective Case–Control Study Evaluating the Role of Mifepristone for Induction of Labor in Women with Previous Cesarean Section. J Obstet Gynecol India 66 (Suppl 1), 30–37 (2016). https://doi.org/10.1007/s13224-015-0760-3

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  • DOI: https://doi.org/10.1007/s13224-015-0760-3

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