Abstract
Purpose
Hyperemesis gravidarum is the third leading cause of hospitalization during pregnancy. 5-HT3-receptor antagonists are the most effective against chemotherapy-induced nausea and vomiting and radiation. This randomized study aimed to compare and evaluate the efficacies of granisetron and promethazine for controlling nausea and vomiting of pregnancy.
Methods
The included patients were administered (oral and intravenous) granisetron and promethazine randomly. The patients were evaluated for nausea and vomiting by a senior gynecology resident blinded to designated drugs.
Results
This study revealed that granisetron significantly decreased nausea and vomiting in pregnant women (p < 0.05). Greater patient satisfaction and lesser adverse drug reactions in women receiving granisetron observed in this study suggest that it can be introduced as a more effective and safer drug in comparison with promethazine.
Conclusions
Considering the prevalence of nausea and vomiting of pregnancy and hyperemesis gravidarum, we can state that it is a health-related problem with economic, social and psychological dimensions. All efforts especially simple outpatient strategies to reduce its severity will help the pregnant woman continue her pregnancy with more satisfaction.
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Acknowledgments
The authors would like to thank the Aburaihan Pharmaceutical Company for their support to this study. Furthermore, we also wish to thank the nursing staff of the Gynecology ward, who kindly participated in our study.
Compliance with Ethical Requirements and Conflict of Interest
The authors also state that the protocol for the research project has been approved by a suitably constituted Ethics Committee of the institution within which the work was undertaken and that it conforms to the provisions of the Declaration of Helsinki (as revised in Tokyo 2004). We state our study does not violate the policies and/or procedures established by journals such as those described in “Specific Inappropriate Acts in Publication Process”. The authors declare that they have no competing interests.
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Ashraf Aleyasin is a Professor in Tehran University of Medical Sciences, Tehran, Iran; Elham Saffarieh is Ob/Gyn Specialist in Tehran University of Medical Sciences, Tehran, Iran; Atossa Mahdavi is Professor Assistant in Tehran University of Medical Sciences, Tehran, Iran.
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Aleyasin, A., Saffarieh, E., Torkamandi, H. et al. Comparison of Efficacy of Granisetron and Promethazine in Control of Hyperemesis Gravidarum. J Obstet Gynecol India 66, 409–414 (2016). https://doi.org/10.1007/s13224-015-0709-6
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DOI: https://doi.org/10.1007/s13224-015-0709-6