Abstract
Objective
The objective of this study was to identify clinical practices worldwide, which would help in recognizing women at risk of excessive bleeding or of developing pelvic infection following trans-vaginal ovum pick-up (TV-OPU), measures taken to minimize risks and their management.
Method
A prospective, web-based questionnaire with distinct questions related to the practice of TV-OPU.
Results
A total of 155 units from 55 countries performing 97,200 IVF cycles annually responded to this web-based survey. A majority (65 %) responded that they would routinely carry out full blood count, while 35 % performed coagulation profile. Less than a third agreed screening women for vaginal infections. About a third used both sterile water and antiseptic to minimize ascending infection, and 52 % used antibiotics for prophylaxis. Doppler ultrasound was routinely used by 20 % of clinicians. 73 % of the clinicians preferred conservative management as their first line management for patients diagnosed with intra-abdominal bleeding.
Conclusion
The study has identified a wide variation in the practices of minimizing infection and bleeding complications. The dearth of good quality evidence may be responsible for the lack of published guidelines, and therefore a lack of consensus on the optimum practice for minimizing the risk of infection and bleeding during TV-OPU.
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References
El-Shawarby S, Margara R, Trew G, et al. A review of complications following transvaginal oocyte retrieval for in vitro fertilization. Hum Fertil (Camb). 2004;2:127–33.
Ludwig AK, Glawatz M, Griesinger G, et al. Perioperative and post-operative complications of transvaginal ultrasound-guided oocyte retrieval: prospective study of >1,000 oocyte retrievals. Hum Reprod. 2006;21(12):3235–40.
Tureck RW, García CR, Blasco L, et al. Perioperative complications arising after transvaginal oocyte retrieval. Obstet Gynecol. 1993;81(4):590–3.
Govaerts I, Devreker F, Delbaere A, et al. Short-term medical complications of 1,500 oocyte retrievals for in vitro fertilization and embryo transfer. Eur J Obstet Gynecol Reprod Biol. 1998;77(2):239–43.
Zhen X, Qiao J, Ma C, et al. Intraperitoneal bleeding following transvaginal oocyte retrieval. Int J Gynaecol Obstet. 2010;108(1):31–4.
Bennett SJ, Waterstone JJ, Cheng WC, et al. Complications of transvaginal ultrasound-directed follicle aspiration: a review of 2,670 consecutive procedures. J Assist Reprod Genet. 1993;10(1):72–7.
Azem F, Wolf Y, Botchan A, et al. Massive retroperitoneal bleeding: a complication of transvaginal ultrasonography-guided oocyte retrieval for in vitro fertilization-embryo transfer. Fertil Steril. 2000;74(2):405–6.
Battaglia C, Regnani G, Giulini S, et al. Severe intraabdominal bleeding after transvaginal oocyte retrieval for IVF-ET and coagulation factor XI deficiency: a case report. J Assist Reprod Genet. 2001;18(3):178–81.
Moayeri SE, Coutre SE, Ramirez EJ, et al. Von Willebrand disease presenting as recurrent hemorrhage after transvaginal oocyte retrieval. Am J Obstet Gynecol. 2007;196(4):e10–1.
El-Shawarby SA, Margara RA, Trew GH, et al. Thrombocythemia and hemoperitoneum after transvaginal oocyte retrieval for in vitro fertilization. Fertil Steril. 2004;82(3):735–7.
Siristatidis C, Chrelias C, Alexiou A, et al. Clinical complications after transvaginal oocyte retrieval: a retrospective analysis. J Obstet Gynaecol. 2013;33(1):64–6.
Fatum M, Ozcan C, Simon A, et al. The safety of ultrasound-guided oocyte pick-up in IVF patients with haemostatic disorders. Eur J Obstet Gynecol Reprod Biol. 2008;137(2):259–61.
Revel A, Schejter-Dinur Y, Yahalomi SZ, et al. Is routine screening needed for coagulation abnormalities before oocyte retrieval? Fertili Steril. 2011;95(3):1182–4.
Liberty G, Hyman JH, Eldar-Geva T, et al. Ovarian hemorrhage after transvaginal ultrasonographically guided oocyte aspiration: a potentially catastrophic and not so rare complication among lean patients with polycystic ovary syndrome. Fertil Steril. 2010;93(3):874–9.
Shalev J, Orvieto R, Meizner I. Use of color Doppler sonography during follicular aspiration in patients undergoing in vitro fertilization may reduce the risk of blood vessel injury. Fertil Steril. 2004;81(5):1408–10.
Serour GI, Aboulghar M, Mansour R, et al. Complications of medically assisted conception in 3,500 cycles. Fertil Steril. 1998;70(4):638–42.
Rísquez F, Confino E. Can Doppler ultrasound-guided oocyte retrieval improve IVF safety? Reprod Biomed Online. 2010;21(4):444–5.
Sharpe K, Karovitch AJ, Claman P, et al. Transvaginal oocyte retrieval for in vitro fertilization complicated by ovarian abscess during pregnancy. Fertil Steril. 2006;86(1):219.
Patounakis G, Krauss K, Nicholas SS, et al. Development of pelvic abscess during pregnancy following transvaginal oocyte retrieval and in vitro fertilization. Eur J Obstet Gynecol Reprod Biol. 2012;164(1):116–7.
Kim JW, Lee WS, Yoon TK, et al. Term delivery following tuboovarian abscess after in vitro fertilization and embryo transfer. Am J Obstet Gynecol. 2013;208(5):e3–6.
Van Os HC, Roozenburg BJ, Janssen-Caspers HA, et al. Vaginal disinfection with povidon iodine and the outcome of in vitro fertilization. Hum Reprod. 1992;7(3):349–50.
Hannoun A, Awwad J, Zreik T, et al. Effect of betadine vaginal preparation during oocyte aspiration in in vitro fertilization cycles on pregnancy outcome. Gynecol Obstet Invest. 2008;66(4):274–8.
Egbase PE, Udo EE, Al-Sharhan M, et al. Prophylactic antibiotics and endocervical microbial inoculation of the endometrium at embryo transfer. Lancet. 1999;354(9179):651–2.
Weinreb EB, Cholst IN, Ledger WJ, et al. Should all oocyte donors receive prophylactic antibiotics for retrieval? Fertil Steril. 2010;94(7):2935–7.
Orvieto R, Ben-Rafael Z. Bleeding, severe pelvic infection and ectopic pregnancy. In: Gardner DK, Weissman A, Howles CM, Shoham Z, editors. Assisted reproductive techniques: laboratory and clinical perspectives. 4th ed. London: Informa Healthcare; 2012. p. 374–81.
Compliance with ethical requirements and Conflict of interest statement
This article does not contain any studies with human or animal subjects. The survey does not involve human subject research and hence a formal Institutional Review Body approval was not obtained. The study was available as an open-access questionnaire to the members of the IVFWorldwide.com who voluntarily answered the study questions, and the data collected for this research were anonymous. The study does not involve the use of laboratory animals. The authors, Dr. Harish Bhandari, Dr. Rina Agrawal, Dr. Ariel Weissman, Mr. Gon Shoham, Prof. Milton Leong, and Prof. Zeev Shoham declare that they have no conflict of interest.
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Bhandari, H., Agrawal, R., Weissman, A. et al. Minimizing the Risk of Infection and Bleeding at Trans-Vaginal Ultrasound-Guided Ovum Pick-up: Results of a Prospective Web-Based World-Wide Survey. J Obstet Gynecol India 65, 389–395 (2015). https://doi.org/10.1007/s13224-014-0619-z
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DOI: https://doi.org/10.1007/s13224-014-0619-z