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Evaluation of Estrogen, Progesterone, and GCDFP-15 Expression in Uterine Leiomyomas

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Abstract

Approximately, one fourth of women have leiomyomas. Leiomyomas are benign tumors that originated from smooth muscle cells. Estrogen is claimed to relate as a cause but exact mechanism has not fully understood. In this study, 95 leiomyoma cases that have been diagnosed by our department in years between 2010 and 2012 were examined. Age ranges of patients, sizes, locations, and numbers of leiomyomas were identified. Immunohistochemically ER (estrogen), PR (progesterone), and Gross cystic disease fluid protein-15 stains were performed to the paraffin blocks and their percentages of staining were noted. Statistically, submucosal and intramural locations were significantly related to ER and PR (p < 0,001). There were significant relationship between ER and PR in 30–50 years age group (p < 0,001). There were significant relationship between ER, PR and locations (p < 0,001), numbers (p < 0,001), sizes of leiomyomas (below 5 cm; p < 0,001), (between 5 and 10 cm; p = 0,037), larger than 10 cm; p = 0,002). Consequently, relationship between leiomyoma and ER, PR were revealed in this study. Also, relationship between leiomyoma locations and patient ages were identified statistically. There was no immunoreactivity with GCDFP-15 in leiomyomas.

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Compliance with ethical requirements and Conflict of interest

All procedures followed were in accordance with the ethical standards of the responsible committee. An ethical clearance has also been taken from the ethical committee (düzce university school of medicine, ethics committee of noninvasive clinical researchers approval for application (decision number:2013/381)).

The authors of the article Havva Erdem, Feyza Baþar, Nilüfer Kadýoðlu, Murat Oktay, Handan Ankaralý, Ali Yavuzcan, Anzel Bahadýr, Serdar Dilbaz declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology, Duzce University of Medical Faculty, Duzce, Turkey

    Havva Erdem Associate Professor, Feyza Başar, Nilüfer Kadıoğlu & Murat Oktay

  2. Department of Biostatistic, Duzce University of Medical Faculty, Duzce, Turkey

    Handan Ankaralı

  3. Department of Obstetrics and Gynecology, Düzce University of Medical Faculty, Duzce, Turkey

    Ali Yavuzcan & Serdar Dilbaz

  4. Department of Biophysics, Duzce University of Medical Faculty, Duzce, Turkey

    Anzel Bahadır

Authors
  1. Havva Erdem Associate Professor
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  2. Feyza Başar
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  3. Nilüfer Kadıoğlu
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  4. Murat Oktay
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  5. Handan Ankaralı
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  6. Ali Yavuzcan
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  7. Anzel Bahadır
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  8. Serdar Dilbaz
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Correspondence to Havva Erdem Associate Professor.

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Erdem, H., Başar, F., Kadıoğlu, N. et al. Evaluation of Estrogen, Progesterone, and GCDFP-15 Expression in Uterine Leiomyomas. J Obstet Gynecol India 65, 335–338 (2015). https://doi.org/10.1007/s13224-014-0617-1

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  • DOI: https://doi.org/10.1007/s13224-014-0617-1

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