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Placental Growth Factor: As an Early Second Trimester Predictive Marker for Preeclampsia in Normal and High-Risk Pregnancies in a Turkish Population

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Abstract

Objective

Placental growth factor (PlGF) is an angiogenetic factor and inducts the development of preeclampsia in a hypoxic environment. In this study, we examined maternal blood PlGF levels in a pregnant population between 16 and 19 weeks of gestation for determining the prospective value for early diagnosis of preeclampsia as a screening test.

Materials and Methods

In this prospective cross-sectional study, 114 nulliparous normotensive pregnant women were selected for the control group and 34 patients who have chronic hypertension or had a medical history of hypertensive disorders in previous pregnancies were selected for the study group.

Results

In the study group, the risk of preeclampsia increased 3.2 times when compared with the control with a confidence interval of 95 %. The cut-off value for PlGF for discriminating preeclamptic and non-preeclamptic patients was found to be 62.5 pg/ml.

Conclusion

Patients with a medical history of hypertensive disorders and low PIGF levels in early second trimester have an increased risk for preeclampsia.

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References

  1. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365:785–99.

    PubMed  Google Scholar 

  2. Iyer S, Acharya KR. Role of placenta growth factor in cardiovascular health. Trends Cardiovasc Med. 2002;12:128–34.

    Article  PubMed  CAS  Google Scholar 

  3. Kyle PM, Buckley D, Kissane J, et al. The angiotensin sensitivity test and low-dose aspirin are ineffective methods to predict and prevent hypertensive disorders in nulliparous pregnancy. Am J Obstet Gynecol. 1995;173(3 Pt 1):865–72.

    Article  PubMed  CAS  Google Scholar 

  4. Vuorela P, Hatva E, Lymboussaki A. Expression of vascular endothelial growth factor and placenta growth factor in human placenta. Biol Reprod. 1997;56:489–94.

    Article  PubMed  CAS  Google Scholar 

  5. Kingdom J, Huppertz B, Seaward G. Development of the placental villous tree and its consequences for fetal growth. Eur J Obstet Gynecol Reprod Biol. 2000;92:35–43.

    Article  PubMed  CAS  Google Scholar 

  6. Rajakumar A, Cerdeira AS, Rana S, et al. Transcriptionally active syncytial aggregates in maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia. Hypertension. 2012;59(2):256–64.

    Article  PubMed  CAS  Google Scholar 

  7. Youssef A, Righetti F, Morano D, et al. Uterine artery doppler and biochemical markers (PPAP-A, PlGF, sFlt-1, P-selectin, NGAL) at 11 + 0 and 13 + 6 weeks in the prediction of late (>34 weeks) pre-eclampsia. Prenat Diagn. 2011;31(12):1141–6.

    PubMed  CAS  Google Scholar 

  8. Soto E, Romero R, Kusanovic JP, et al. Late-onset preeclampsia is associated with an imbalance of angiogenic and anti-angiogenic factors in patients with and without placental lesions consistent with maternal underperfusion. J Matern Fetal Neonatal Med. 2011;25(5):498–507.

    Article  PubMed  Google Scholar 

  9. Torry DS, Wang HS, Wang TH, et al. Preeclampsia is associated with reduced serum levels of placenta growth factor. Am J Obstet Gynecol. 1998;179(6 Pt 1):1539–44.

    Article  PubMed  CAS  Google Scholar 

  10. Maynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111(5):649–58.

    PubMed  CAS  Google Scholar 

  11. Golara M, Benedict A, Jones C, et al. Inflationary oscillometry provides accurate measurement of blood pressure in pre-eclampsia. BJOG. 2002;109:1143–7.

    Article  PubMed  Google Scholar 

  12. National High Blood Pressure Education Program Working Group. Report of the National High Blood Pressure Education Program Working Group on high blood pressure in pregnancy. Am J Obstet Gynecol. 2000;183:S1–22.

    Article  Google Scholar 

  13. Swets JA. Signal detection theory and ROC analysis in psychology and diagnostics: collected papers. Mahwah: Lawrence Erlbaum Associates; 1996.

    Google Scholar 

  14. Cuckle HS. Screening for pre-eclampsia-lessons from aneuploidy screening. Placenta. 2011;32:42–8.

    Article  Google Scholar 

  15. Tidwell SC, Ho HN, Chiu WH, et al. Low maternal serum levels of placenta growth factor as an antecedent of clinical preeclampsia. Am J Obstet Gynecol. 2001;184(6):1267–72.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors offer special thanks to Dr. Leyla Mollamahmutoğlu, the head of the Zekai Tahir Burak Women’s Health, Education, and Research Hospital, the Biochemistry laboratory employees, and Dr. Üran Büyükkağnıcı, the laboratory chief.

Conflict of interest

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Authors and Affiliations

  1. Department of Perinatology, Zekai Tahir Burak Women’s Health Education and Research Hospital, Talatpaşa Bulvarı, Samanpazarı, Ankara, Turkey

    Necmiye Dover (Specialist), Hacer C. Gulerman (Associate Professor), Sevki Celen (Specialist), Serkan Kahyaoglu (Specialist) & Okan Yenicesu (Specialist)

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  1. Necmiye Dover
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  2. Hacer C. Gulerman
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  3. Sevki Celen
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  4. Serkan Kahyaoglu
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  5. Okan Yenicesu
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Correspondence to Necmiye Dover.

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Dover, N., Gulerman, H.C., Celen, S. et al. Placental Growth Factor: As an Early Second Trimester Predictive Marker for Preeclampsia in Normal and High-Risk Pregnancies in a Turkish Population. J Obstet Gynecol India 63, 158–163 (2013). https://doi.org/10.1007/s13224-012-0279-9

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  • DOI: https://doi.org/10.1007/s13224-012-0279-9

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